中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2011年
16期
23-25
,共3页
翟迎九%方铭喜%冯思源%方琦%杨燕萍
翟迎九%方銘喜%馮思源%方琦%楊燕萍
적영구%방명희%풍사원%방기%양연평
糖尿病,2型%脂肪酸类,非酯化%胰岛素强化治疗
糖尿病,2型%脂肪痠類,非酯化%胰島素彊化治療
당뇨병,2형%지방산류,비지화%이도소강화치료
Diabetes mellitus,type 2%Fatty acids,nonesterified%Intensive insulin treatment
目的 探讨短期胰岛素强化治疗对初发2型糖尿病(T2DM)患者血清游离脂肪酸(FFA)的影响.方法 对64例初发T2DM患者进行短期胰岛素强化治疗,治疗前和治疗达标后检测空腹血糖(FPG)、餐后2h血糖(2hPG)、血脂、空腹胰岛素(FINS)、血清FFA.结果 短期胰岛素强化治疗达标后T2DM患者FPG、2hPG、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、FFA、稳态模型胰岛素抵抗指数(HOMA-IR)分别为(9.68±2.02)mmol/L、(12.77±1.35)mmol/L、(4.26±1.07) mmol/L、(1.52±0.58)mmol/L、(2.50±0 75)mmol/L、(435 84±190.94)μmol/L、0.51±0.62,均较治疗前的(14.66±3.50)mmol/L、(17.43±4.89)mmol/L、(5.03±0.94)mmol/L、(2.05±1.42)mmol/L、(2.91±0.78)mmol/L、(586.68±229.45)μmol/L、0.65±0.89显著下降(P＜0.05),稳态模型胰岛素分泌指数(HOMA-β)为2.70±0.83,较治疗前的1.74±1.04显著升高(P＜0.05),并且HOMA-β的升高、HOMA-IR的下降与FFA的下降呈正相关.结论 短期胰岛素强化治疗可以明显降低初发T2DM患者的血清FFA水平,有利于胰岛细胞功能及胰岛素抵抗的改善.
目的 探討短期胰島素彊化治療對初髮2型糖尿病(T2DM)患者血清遊離脂肪痠(FFA)的影響.方法 對64例初髮T2DM患者進行短期胰島素彊化治療,治療前和治療達標後檢測空腹血糖(FPG)、餐後2h血糖(2hPG)、血脂、空腹胰島素(FINS)、血清FFA.結果 短期胰島素彊化治療達標後T2DM患者FPG、2hPG、總膽固醇(TC)、三酰甘油(TG)、低密度脂蛋白膽固醇(LDL-C)、FFA、穩態模型胰島素牴抗指數(HOMA-IR)分彆為(9.68±2.02)mmol/L、(12.77±1.35)mmol/L、(4.26±1.07) mmol/L、(1.52±0.58)mmol/L、(2.50±0 75)mmol/L、(435 84±190.94)μmol/L、0.51±0.62,均較治療前的(14.66±3.50)mmol/L、(17.43±4.89)mmol/L、(5.03±0.94)mmol/L、(2.05±1.42)mmol/L、(2.91±0.78)mmol/L、(586.68±229.45)μmol/L、0.65±0.89顯著下降(P＜0.05),穩態模型胰島素分泌指數(HOMA-β)為2.70±0.83,較治療前的1.74±1.04顯著升高(P＜0.05),併且HOMA-β的升高、HOMA-IR的下降與FFA的下降呈正相關.結論 短期胰島素彊化治療可以明顯降低初髮T2DM患者的血清FFA水平,有利于胰島細胞功能及胰島素牴抗的改善.
목적 탐토단기이도소강화치료대초발2형당뇨병(T2DM)환자혈청유리지방산(FFA)적영향.방법 대64례초발T2DM환자진행단기이도소강화치료,치료전화치료체표후검측공복혈당(FPG)、찬후2h혈당(2hPG)、혈지、공복이도소(FINS)、혈청FFA.결과 단기이도소강화치료체표후T2DM환자FPG、2hPG、총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDL-C)、FFA、은태모형이도소저항지수(HOMA-IR)분별위(9.68±2.02)mmol/L、(12.77±1.35)mmol/L、(4.26±1.07) mmol/L、(1.52±0.58)mmol/L、(2.50±0 75)mmol/L、(435 84±190.94)μmol/L、0.51±0.62,균교치료전적(14.66±3.50)mmol/L、(17.43±4.89)mmol/L、(5.03±0.94)mmol/L、(2.05±1.42)mmol/L、(2.91±0.78)mmol/L、(586.68±229.45)μmol/L、0.65±0.89현저하강(P＜0.05),은태모형이도소분비지수(HOMA-β)위2.70±0.83,교치료전적1.74±1.04현저승고(P＜0.05),병차HOMA-β적승고、HOMA-IR적하강여FFA적하강정정상관.결론 단기이도소강화치료가이명현강저초발T2DM환자적혈청FFA수평,유리우이도세포공능급이도소저항적개선.
Objective To study the effect of transient intensive insulin treatment on the serum free fatty acid (FFA) in newly diagnosed type 2 diabetic patients.Methods Sixty-four newly diagnosed type 2 diabetic patients were treated with transient intensive insulin.The fasting plasma glucose (FPG),2 hours post-prandial glucose (2hPG),lipid,fastin insulin (FINS),and serum FFA was examined hefore and after treatment.Results The levels of FPG,2hPG,total cholesterol (TC),triglycerides (TG),low density lipoproteins cholesterol (LDL-C),FFA and HOMA-IR after treatment were (9.68 ± 2.02) mmol/L,(12.77 ± 1.35) mmol/L,(4.26 ± 1.07) mmol/L,(1.52 ± 0.58) mmol/L,(2.50 ±0.75) mmol/L,(435.84 ± 190.94) μmol/L,0.51 ± 0.62,and they decreased obviously compared with those before treatment [(14.66 ± 3.50) mmol/L,(17.43 ±4.89) mmol/L,(5.03 ±0.94) mmol/L,(2.05 ± 1.42) mmol/L,(2.91 ±0.78) mmol/L,(586.68 ±229.45)μmol/L,0.65 ± 0.89](P＜0.05).The level of HOMA-β increased obviously (2.70 ± 0.83 vs.1.74 ± 1.04)(P＜0.05).The increase of HOMA-β and the decrease of HOMA-IR was positively correlated with the decrease of FFA.Conclusion The transient intensive insulin treatment can evidently decrease the level of FFA that can improve beta-cell function and relieve insulin resistance in newly diagnosed type 2 diabetic patients.
