中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2008年
10期
1060-1062
,共3页
颈动脉%动脉粥样硬化%内中膜厚度%白介素-6%白介素-18
頸動脈%動脈粥樣硬化%內中膜厚度%白介素-6%白介素-18
경동맥%동맥죽양경화%내중막후도%백개소-6%백개소-18
Carotid artery%Artherosclerosis%Intimal-medial thickness%Interleukin-6%Interleukin-18
目的 探讨急性脑梗死(ACI)患者血清细胞因子白介素-6(IL-6)、白介素-18(IL-18)水平与颈动脉内中膜厚度(IMT)的关系.方法 以64例ACI患者作为ACI组,30例健康体检者为正常对照组,利用放射免疫法(RIA)和酶联吸附法(ELISA)分别测定其血清IL-6和IL-18水平,分别测量其颈动脉内中膜厚度(IMT)值并分为IMT<1.0mm和IMT≥1.0mm两个亚组.结果 ACI组中IMT≥1.0mm者IL-6、IL-18含量与正常对照组相比差异有统计学意义(P<0.05),与IMT<1.0mm者相比差异亦有统计学意义(P<0.05).ACI组中IMT≥1.0mm者IMT与IL-18水平呈明显正相关(r=0.549,P=0.001),与IL-6水平无明显相关性(P>0.05).结论 ACI患者IMT增厚者血清IL-6、IL-18水平也升高.
目的 探討急性腦梗死(ACI)患者血清細胞因子白介素-6(IL-6)、白介素-18(IL-18)水平與頸動脈內中膜厚度(IMT)的關繫.方法 以64例ACI患者作為ACI組,30例健康體檢者為正常對照組,利用放射免疫法(RIA)和酶聯吸附法(ELISA)分彆測定其血清IL-6和IL-18水平,分彆測量其頸動脈內中膜厚度(IMT)值併分為IMT<1.0mm和IMT≥1.0mm兩箇亞組.結果 ACI組中IMT≥1.0mm者IL-6、IL-18含量與正常對照組相比差異有統計學意義(P<0.05),與IMT<1.0mm者相比差異亦有統計學意義(P<0.05).ACI組中IMT≥1.0mm者IMT與IL-18水平呈明顯正相關(r=0.549,P=0.001),與IL-6水平無明顯相關性(P>0.05).結論 ACI患者IMT增厚者血清IL-6、IL-18水平也升高.
목적 탐토급성뇌경사(ACI)환자혈청세포인자백개소-6(IL-6)、백개소-18(IL-18)수평여경동맥내중막후도(IMT)적관계.방법 이64례ACI환자작위ACI조,30례건강체검자위정상대조조,이용방사면역법(RIA)화매련흡부법(ELISA)분별측정기혈청IL-6화IL-18수평,분별측량기경동맥내중막후도(IMT)치병분위IMT<1.0mm화IMT≥1.0mm량개아조.결과 ACI조중IMT≥1.0mm자IL-6、IL-18함량여정상대조조상비차이유통계학의의(P<0.05),여IMT<1.0mm자상비차이역유통계학의의(P<0.05).ACI조중IMT≥1.0mm자IMT여IL-18수평정명현정상관(r=0.549,P=0.001),여IL-6수평무명현상관성(P>0.05).결론 ACI환자IMT증후자혈청IL-6、IL-18수평야승고.
Objective To investigate the correlation of serum interleukin-6 (IL-6) and IL-18levels to carotid artery intimal-medial thickness (IMT) in patients with acute cerebral infarction (ACI).Methods In 64 patients with ACI and 30 healthy volunteers, serum IL-6 and IL-18 levels were detectedusing radioimmunoassay and enzyme-linked immunosorbent assay (ELISA), respectively. Carotid arteryIMT were measured in the two groups using color Doppler ultrasound, and the ACI patients were dividedinto two groups with carotid IMT greater or lower than 1.0 mm. Results The ACI patients and thehealthy volunteers showed significant differences in serum IL-6 (P<0.05) and IL-18 levels (P<0.05),which were also significantly different between ACI patients with carotid IMT ≥ 1.0 mm and those withIMT<1.0 mm (P<0.05). The ACI patients with IMT<1.0 mm had comparable serum IL-6 and IL-18 levelsto those in the healthy volunteers. In patients with carotid IMT ≥ 1.0 mm, the serum IL-18 level waspositively correlated to IMT (r=0.549, P=0.001), but the IL-6 level was not related to IMT (P>0.05).Conclusion The serum levels of IL-6 and IL-18 are elevated in ACI patients with increased carotid IMT.
