CAJ | 학술논문

视网膜变性疾病是一组由视网膜光感受器细胞变性、凋亡所致的严重致盲性眼病,至今仍无彻底的根治方法.多潜能干细胞是一种通过将体细胞重编程为类似胚胎干细胞的多潜能细胞,具有无限增殖、多向分化潜能和记忆能力等特点.目前有不少研究者将多潜能干细胞诱导分化为视网膜细胞,并应用于视网膜疾病的细胞移植治疗、发病机制研究及药物毒性评价等方面,这将为视网膜变性疾病的治疗提供新的研究思路和方法.
시망막변성질병시일조유시망막광감수기세포변성、조망소치적엄중치맹성안병,지금잉무철저적근치방법.다잠능간세포시일충통과장체세포중편정위유사배태간세포적다잠능세포,구유무한증식、다향분화잠능화기억능력등특점.목전유불소연구자장다잠능간세포유도분화위시망막세포,병응용우시망막질병적세포이식치료、발병궤제연구급약물독성평개등방면,저장위시망막변성질병적치료제공신적연구사로화방법.
Retinal degeneration diseases are a group of severe eye diseases that can lead to blindness.They are characterized by degeneration and apoptosis of photoreceptor cells and still lacking effective therapeutic procedures.Pluripotent stem cells (induced pluripotent stem cells,iPS cells) obtained from somatic cell reprogramming are similar to the embryonic stem cells (embryonic stem cells,ES cells),which have unlimited proliferation,differentiation and memory characteristics.Retinal cells from iPS cells have been used in cell transplantation for the treatment of retinal diseases,for the study of pathogenesis and drug toxicity evaluation in retinal degenerative diseases.This may provide new ideas and novel procedures for the treatment of retinal degenerative diseases in the future.