中国化学快报(英文版)
中國化學快報(英文版)
중국화학쾌보(영문판)
CHINESE CHEMICAL LETTERS
2004年
4期
419-422
,共4页
Endophytic fungus,sterols,ergosta-8(9),22-diene-3,5,6,7-tetraol (3β,5α,6β,7α,22E),cytotoxicity
A new sterol,ergosta-8(9),22-diene-3,5,6,7-tetraol(3β,5α,6β,7α,22E)(A)together with three known sterols:3β,5α,6β-trihydroxyergosta-7,22-diene(B),3β-hydroxy-5α,8α-epidioxyer-gosta-6,22-diene(C)and ergosterol(D)were isolated from the mycelia of an unidentified endophytic fungus separated from Castaniopsis fissa(chestnut tree).Compound A exhibited potent selective cytotoxicity against Bel-7402,NCI4460 and L-02 cell lines with IC50values 8.445,5.03,13.621μg/mL,respectively.
