CAJ | 학술논문

目的:探讨亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与新疆哈族、汉族食管癌易感性的关系.方法:用PCR-RFLP方法检测食管癌患者178例(哈萨克族94例,汉族84例)和同一地区无肿瘤病史的正常对照者155例(哈萨克族98例,汉族57例)的MTHFR基因C677T基因型分布.结果:新疆哈族食管癌组中MTHFR C677T3种基因型C C,CT,TT,所占比例分别是56.4%,36.2%,7.4%,与新疆汉族食管癌组中的32.9%,40.0%,27.1%相比,存在显著差异(x2=15.37,P＜0.05);哈族正常对照组分别为58.2%,29.6%,12.2%与汉族正常对照组22.8%,52.6%,24.6%相比,有显著差异(x2=18.26,P＜0.05).MTHFR 3种基因型在哈族食管癌组中的分布(CC 56.4%,CT 36.2%and TT7.4%)与对照组中(CC 22.8%,CT 52.6%and TT 24.6%)相比,无显著差异(x2=1.776,P=0.412).在汉族食管癌组与对照组间也无显著差异(x2=2.750,P=0.253).结论:MTHFR C677T基因多态性分布在新疆哈族、汉族正常对照组间存在民族差异,在食管癌间也存在差异.MTHFR C677T基因多态性可能与新疆哈萨克族与汉族食管癌的易感性无关.
목적:탐토아갑기사경협산환원매(MTHFR)기인C677T다태성여신강합족、한족식관암역감성적관계.방법:용PCR-RFLP방법검측식관암환자178례(합살극족94례,한족84례)화동일지구무종류병사적정상대조자155례(합살극족98례,한족57례)적MTHFR기인C677T기인형분포.결과:신강합족식관암조중MTHFR C677T3충기인형C C,CT,TT,소점비례분별시56.4%,36.2%,7.4%,여신강한족식관암조중적32.9%,40.0%,27.1%상비,존재현저차이(x2=15.37,P＜0.05);합족정상대조조분별위58.2%,29.6%,12.2%여한족정상대조조22.8%,52.6%,24.6%상비,유현저차이(x2=18.26,P＜0.05).MTHFR 3충기인형재합족식관암조중적분포(CC 56.4%,CT 36.2%and TT7.4%)여대조조중(CC 22.8%,CT 52.6%and TT 24.6%)상비,무현저차이(x2=1.776,P=0.412).재한족식관암조여대조조간야무현저차이(x2=2.750,P=0.253).결론:MTHFR C677T기인다태성분포재신강합족、한족정상대조조간존재민족차이,재식관암간야존재차이.MTHFR C677T기인다태성가능여신강합살극족여한족식관암적역감성무관.