中国民族民间医药
中國民族民間醫藥
중국민족민간의약
CHINESE JOURNAL OF ETHNOMEDICINE AND ETHNOPHARMACY
2009年
13期
46-47,115
,共3页
牛膝多糖(ABP)%荷瘤S180%肝癌H22%抗种瘤作用%白细胞(Wbc)%回升作用
牛膝多糖(ABP)%荷瘤S180%肝癌H22%抗種瘤作用%白細胞(Wbc)%迴升作用
우슬다당(ABP)%하류S180%간암H22%항충류작용%백세포(Wbc)%회승작용
Achyranthes Bidentata polysaccharides (ABP)%sarcoma 180 (S180)%Hepatocarcinoma22 (H22)%Anti-tumor activity%Leucocyte (WBC)%Resuscitate activity
目的:观察川牛膝多糖对S180荷瘤小鼠、H22肝癌小鼠的肿瘤抑制作用以及川牛膝多糖对环磷酰胺(Cy)所致小鼠(正常及荷瘤小鼠)外周白细胞减少的影响.方法:以动物移植性肿瘤荷瘤S180、肝癌为模型,环磷酰胺(Cy)为阳性对照,生理盐水为阴性对照,观察川牛膝多糖抗肿瘤作用;通过白细胞计数观察川牛膝多糖对环磷酰胺(Cy)所致外周白细胞减少的回升作用.结果:川牛膝多糖对S180荷瘤小鼠的抑瘤率为10.00-48.08%;对肝癌H22实体瘤的小鼠肝癌H22的抑制率为21.99-42.21%;对环磷酰胺(Cy)所致正常或荷瘤小鼠外周血白细胞减少有极显著的回升作用.结论:川牛膝多糖不仅有较强的抗肿瘤作用,还能对环磷酰胺(Cy)所致小鼠(正常及荷瘤小鼠)外周白细胞减少有明显的回升作用.
目的:觀察川牛膝多糖對S180荷瘤小鼠、H22肝癌小鼠的腫瘤抑製作用以及川牛膝多糖對環燐酰胺(Cy)所緻小鼠(正常及荷瘤小鼠)外週白細胞減少的影響.方法:以動物移植性腫瘤荷瘤S180、肝癌為模型,環燐酰胺(Cy)為暘性對照,生理鹽水為陰性對照,觀察川牛膝多糖抗腫瘤作用;通過白細胞計數觀察川牛膝多糖對環燐酰胺(Cy)所緻外週白細胞減少的迴升作用.結果:川牛膝多糖對S180荷瘤小鼠的抑瘤率為10.00-48.08%;對肝癌H22實體瘤的小鼠肝癌H22的抑製率為21.99-42.21%;對環燐酰胺(Cy)所緻正常或荷瘤小鼠外週血白細胞減少有極顯著的迴升作用.結論:川牛膝多糖不僅有較彊的抗腫瘤作用,還能對環燐酰胺(Cy)所緻小鼠(正常及荷瘤小鼠)外週白細胞減少有明顯的迴升作用.
목적:관찰천우슬다당대S180하류소서、H22간암소서적종류억제작용이급천우슬다당대배린선알(Cy)소치소서(정상급하류소서)외주백세포감소적영향.방법:이동물이식성종류하류S180、간암위모형,배린선알(Cy)위양성대조,생리염수위음성대조,관찰천우슬다당항종류작용;통과백세포계수관찰천우슬다당대배린선알(Cy)소치외주백세포감소적회승작용.결과:천우슬다당대S180하류소서적억류솔위10.00-48.08%;대간암H22실체류적소서간암H22적억제솔위21.99-42.21%;대배린선알(Cy)소치정상혹하류소서외주혈백세포감소유겁현저적회승작용.결론:천우슬다당불부유교강적항종류작용,환능대배린선알(Cy)소치소서(정상급하류소서)외주백세포감소유명현적회승작용.
Objective: observing on Achyranthes Bidentata Polysacharides (ABP) inhibit tumor of sacoma 180 (S180) mice and Hepatocarci-noma22 (H22) mice,and affect on mice (normal or (S180) that received Cyclopsosphamide (Cy) which leaded extra-leucocytopenia Methods By means of removed S180 and Hepatocarcinoma mice as a roodel,Cyclopsosphamide as positive contrast ,compared with normal saline group,obsersve ABP action on anti-tumor.Observing on ABP resuscitate action . Results The anti-tumor rate to S180 tumor model mice of ABP is10.00-48.08%; Hepatocarcinoma22 model mice is 21.99-42.21%.ABP can transparently resuscitate extra-leucocytopenia of mice (normal or SI80) that lead by Cylophamide.Conclusion ABP can not only has fairly strong anti-tumor action,but also can transparently resuscitate extra-leucocytopenia of mice (normal or S180) that leaded by Cyclophosphamide.
