CAJ | 학술논문

目的:阐明影响肺腺癌脑转移患者生存的因素,为临床治疗的决策提供参考依据.方法对本院109例死亡的肺腺癌脑转移患者之临床资料进行回顾性分析,生存期>1年者57例,<1年者52例.使用SPSS15.0分析统计软件进行数据分析,P<0.05为差别有显著性.结果:单因素和多因素分析均显示患者的PS评分、脑转移出现时间及脑转移的治疗方法是影响肺腺癌脑转移患者生存期的独立的预后因素(P<0.05).而患者的性别、年龄、有无脑转移症状及有无颅外器官转移对其生存期无显著影响.结论:PS评分为0～1,脑转移出现时间>1年和应用综合治疗方法的肺腺癌脑转移患者长生存期较长.
목적:천명영향폐선암뇌전이환자생존적인소,위림상치료적결책제공삼고의거.방법대본원109례사망적폐선암뇌전이환자지림상자료진행회고성분석,생존기>1년자57례,<1년자52례.사용SPSS15.0분석통계연건진행수거분석,P<0.05위차별유현저성.결과:단인소화다인소분석균현시환자적PS평분、뇌전이출현시간급뇌전이적치료방법시영향폐선암뇌전이환자생존기적독립적예후인소(P<0.05).이환자적성별、년령、유무뇌전이증상급유무로외기관전이대기생존기무현저영향.결론:PS평분위0～1,뇌전이출현시간>1년화응용종합치료방법적폐선암뇌전이환자장생존기교장.
Objective: To investigate prognostic factors of survival of lung adenocarcinoma patients with brain metasta-ses.Methods: The clinical data of 109 lung adenocarcinoma patients with brain metastases were reviewed.Fifty-senven pa-tients survived more than 1 year, and 52 patients survived less than 1 year.The data were analyzed by SPSS 15.0 statisti-cal software.Results: Both the univariate analysis and multivariate analysis showed that patients' PS score, the interval be-tween diagnosis and brain metastasis, and multimodality treatment were independent prognostic factors for the survival of lung adenocarcinoma patients with brain metastases (P<0.05).Patients' gender, age, metastatic symptoms and extracrani-al metastases didn't significantly affect patient survival.Conclusion: Patients with PS score 0-1, the interval of more than 1 year between diagnosis and brain metastasis, and combined therapy have longer survival.The research provides an impor-tant guidance for the treatment of advanced lung adenocarcinoma patients with brain metastases.