CAJ | 학술논문

性发育是青春发育开始直至具有生育能力的一个序贯过程.特发性中枢性性早熟指未发现中枢神经系统器质性病变的性早熟,其确切病因和触发机制尚未完全阐明,受体内外诸多因素影响,如遗传因素、代谢因素、环境因素等.其中遗传因素对青春期启动时问的决定作用占50%～80%,涉及神经内分泌因素(KiSS-1/G蛋白耦联受体54系统、神经递质、生长因子)和染色体异常.现就特发性中枢性性早熟的病因和分子机制方面的研究进展作一综述.
성발육시청춘발육개시직지구유생육능력적일개서관과정.특발성중추성성조숙지미발현중추신경계통기질성병변적성조숙,기학절병인화촉발궤제상미완전천명,수체내외제다인소영향,여유전인소、대사인소、배경인소등.기중유전인소대청춘기계동시문적결정작용점50%～80%,섭급신경내분비인소(KiSS-1/G단백우련수체54계통、신경체질、생장인자)화염색체이상.현취특발성중추성성조숙적병인화분자궤제방면적연구진전작일종술.
Puberty is a transition between childhood and the adult reproductive stage. Idiopathic central precocious puberty has no associated lesion of the central nervous system. The exact triggers have not yet been elucidated. Puberty development is a multifaceted process that is under control of different regulatory mechanisms such as genetic, metabolic and environmental factors. About 50%-80% of the calculated measures of heritability of puberty are of genetic origin. Neuroendocrine factors ( KiSS-1/GPR54 system, neurotransmitters, growth factor) and chromosome abnormality are also involved. Advance in research of etiology of idiopathic central precocious puberty will be reviewed here.