CAJ | 학술논문

胸腺素β4是由43个氨基酸组成的高度保守的水溶性多肽,存在于除红细胞外的所有真核细胞中.它可以和G-actin结合,抑制F-actin的形成,从而影响细胞骨架,被认为是细胞中主要的肌动蛋白调节因子.细胞外的胸腺素β4有多种生物学功能,包括促进血管生成、加速内皮细胞迁移、调节炎症反应和神经系统发育等.它有可能成为促进角膜、皮肤和心脏创伤愈合的新的治疗药物.
흉선소β4시유43개안기산조성적고도보수적수용성다태,존재우제홍세포외적소유진핵세포중.타가이화G-actin결합,억제F-actin적형성,종이영향세포골가,피인위시세포중주요적기동단백조절인자.세포외적흉선소β4유다충생물학공능,포괄촉진혈관생성、가속내피세포천이、조절염증반응화신경계통발육등.타유가능성위촉진각막、피부화심장창상유합적신적치료약물.
Thymosin beta 4(Tβ4) is a highly conserved,water-soluble,43-amino acid acidic polypeptide.It widely exist in tissues and circulating cells except red blood cells.It can bind to G-actin and inhibit F-actin formatting.Thus,Tβ4 functions as a major G-actin sequestering factor that modulates dynamic changes of actin cytoskeleton.In addition,Tβ4 involves in a variety of physiologic and pathologic processes,including promoting angiogenesis,stimulating endothelial migration,regulating inflammation and nervous system development.It may be a new medicine for promoting cornea,skin and heart wound healing.