中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2010年
25期
21-24
,共4页
脑缺血发作,短暂性%基质金属蛋白酶9%预后
腦缺血髮作,短暫性%基質金屬蛋白酶9%預後
뇌결혈발작,단잠성%기질금속단백매9%예후
Ischemic attack,transient%Matrix metalloproteinase 9%Prognosis
目的 探讨血清基质金属蛋白酶-9(MMP-9)水平与短暂性脑缺血发作(TIA)预后的关系.方法 选择64例TIA患者(TIA组),同时选择与其性别、年龄等匹配的非脑血管病的体检者64例作为对照组,采用ELISA法检测两组MMP-9水平,并进行比较.对入选者随访4年,分析MMP-9水平与TIA预后的关系.结果 TIA组MMP-9水平[(5.25±0.51)μg/L]显著高于对照组[(3.25±0.39)μg/L](t=7.830,P<0.05);TIA组在4年随访中发生一级终点事件患者MMP-9水平显著高于未发生一级终点事件患者[(5.78±0.48)μg/L比(3.15±0.29)μg/L,t=3.250,P<0.05].TIA患者中,高MMP-9水平者(>4.5μg/L)较低MMP-9水平者(<2.5 μg/L)发生一级终点事件的相对危险度为2.612(95% CI 1.557～5.463,P<0.01).在排除年龄、性别、体重指数、血脂水平、吸烟史以及高血压、糖尿病病史影响后,高MMP-9水平者发生一级终点事件的危险度显著高于低MMP-9水平者(OR=2.346,95% CI 1.418～5.216,P=0.006).结论 MMP-9水平与TIA患者的预后有关,提示炎性反应在TIA发病中起重要作用,可能成为评估TIA预后的标志物之一.
目的 探討血清基質金屬蛋白酶-9(MMP-9)水平與短暫性腦缺血髮作(TIA)預後的關繫.方法 選擇64例TIA患者(TIA組),同時選擇與其性彆、年齡等匹配的非腦血管病的體檢者64例作為對照組,採用ELISA法檢測兩組MMP-9水平,併進行比較.對入選者隨訪4年,分析MMP-9水平與TIA預後的關繫.結果 TIA組MMP-9水平[(5.25±0.51)μg/L]顯著高于對照組[(3.25±0.39)μg/L](t=7.830,P<0.05);TIA組在4年隨訪中髮生一級終點事件患者MMP-9水平顯著高于未髮生一級終點事件患者[(5.78±0.48)μg/L比(3.15±0.29)μg/L,t=3.250,P<0.05].TIA患者中,高MMP-9水平者(>4.5μg/L)較低MMP-9水平者(<2.5 μg/L)髮生一級終點事件的相對危險度為2.612(95% CI 1.557～5.463,P<0.01).在排除年齡、性彆、體重指數、血脂水平、吸煙史以及高血壓、糖尿病病史影響後,高MMP-9水平者髮生一級終點事件的危險度顯著高于低MMP-9水平者(OR=2.346,95% CI 1.418～5.216,P=0.006).結論 MMP-9水平與TIA患者的預後有關,提示炎性反應在TIA髮病中起重要作用,可能成為評估TIA預後的標誌物之一.
목적 탐토혈청기질금속단백매-9(MMP-9)수평여단잠성뇌결혈발작(TIA)예후적관계.방법 선택64례TIA환자(TIA조),동시선택여기성별、년령등필배적비뇌혈관병적체검자64례작위대조조,채용ELISA법검측량조MMP-9수평,병진행비교.대입선자수방4년,분석MMP-9수평여TIA예후적관계.결과 TIA조MMP-9수평[(5.25±0.51)μg/L]현저고우대조조[(3.25±0.39)μg/L](t=7.830,P<0.05);TIA조재4년수방중발생일급종점사건환자MMP-9수평현저고우미발생일급종점사건환자[(5.78±0.48)μg/L비(3.15±0.29)μg/L,t=3.250,P<0.05].TIA환자중,고MMP-9수평자(>4.5μg/L)교저MMP-9수평자(<2.5 μg/L)발생일급종점사건적상대위험도위2.612(95% CI 1.557～5.463,P<0.01).재배제년령、성별、체중지수、혈지수평、흡연사이급고혈압、당뇨병병사영향후,고MMP-9수평자발생일급종점사건적위험도현저고우저MMP-9수평자(OR=2.346,95% CI 1.418～5.216,P=0.006).결론 MMP-9수평여TIA환자적예후유관,제시염성반응재TIA발병중기중요작용,가능성위평고TIA예후적표지물지일.
Objective To investigate the effect of matrix metalloproteinase-9 (MMP-9) on the prognosis of transient ischemic attack(TIA). Methods Sixty-four patients with first-onset TIA(TIA group)and 64 age and sex matched cases without any cerebrovascular disease (control group) were involved in this study. The level of MMP-9 was measured by ELISA method,and the subsequent vascular events and death rate were determined in both groups over 4 years. Results The level of MMP-9 in TIA group was significantly higher than that in control group [(5.25 ± 0.51 ) μg/L vs. (3.25 ± 0.39 ) μg/L, t = 7.830, P <0.05]. Furthermore, in TIA group, the level of MMP-9 was significantly higher in patients with primary endpoint events than that in the patients without primary endpoint events [(5.78 ± 0.48) μg/L vs. (3.15 ±0.29) μg/L, t = 3.250, P < 0.05]. Compared with the patients with lower MMP-9 level ( < 2.5 μg/L), the relative risk of primary endpoint events in higher MMP-9 level patients ( > 4.5 μg/L) was 2.612 (95% CI 1.557-5.463 ,P < 0.01 ) in TIA group. This increased relative risk for primary endpoint events in TIA group persisted after the adjustment for age, sex, body mass index, blood fat level and other cardiovascular risk factors such as hypertension, diabetes and smoking (OR =2.346,95% CI 1.418-5.216,P =0.006).Conclusions The level of MMP-9 in TIA patients has relationship with prognosis and inflammation may play an important role in TIA. MMP-9 may be a marker in predicting prognosis.
