CAJ | 학술논문

目的探讨白血病及淋巴瘤患者中经外周置人中心静脉导管(PICC)术后机械性静脉炎的发病率及其与全身炎症反应水平的关系.方法选取首次进行化疗且接受PICC术的白血病患者(68例)及淋巴瘤患者(37例)为研究对象,比较两组PICC术后机械性静脉炎的发病率、外周血白细胞(WBC)计数及C反应蛋白(CRP)的水平并研究其相关性.结果白血病组静脉炎发病率(35.3％)高于淋巴瘤组(10.8％),差异具有统计学意义(x2=7.345,P＜0.01).白血病组中机械性静脉炎患者的外周血WBC计数(17.4±5.48)×109/L,显著高于非静脉炎患者(6.13±2.31)×109/L,差异具有统计学意义(t=11.9,P＜0.05),且WBC计数水平与静脉炎级别呈正相关(r=0.998,P＜0.05).而淋巴瘤组中机械性静脉炎患者的外周血WBC计数与非静脉炎患者差异无统计学意义(P＞0.05),且WBC计数水平与静脉炎级别无相关关系(P＞0.05).白血病组中静脉炎患者的血CRP(48.80±21.10)mg/L显著高于非静脉炎患者(13.90±5.51) mg/L,差异具有统计学意义(t=10.4,P＜0.05),且血CRP水平与静脉炎级别呈正相关(r =0.989,P＜0.05).淋巴瘤组静脉炎患者CRP(37.0±7.74) mg/L显著高于非静脉炎患者(12.8±5.84) mg/L,差异具有统计学意义(t=7.88,P＜0.05),但与静脉炎级别无相关关系(P＞0.05).结论在白血病及淋巴瘤患者中,发生PICC术后机械性静脉炎患者具有较高的全身炎症反应水平,提示在临床工作中对于这类患者应加强静脉炎的预防及护理.
목적 탐토백혈병급림파류환자중경외주치인중심정맥도관(PICC)술후궤계성정맥염적발병솔급기여전신염증반응수평적관계.방법 선취수차진행화료차접수PICC술적백혈병환자(68례)급림파류환자(37례)위연구대상,비교량조PICC술후궤계성정맥염적발병솔、외주혈백세포(WBC)계수급C반응단백(CRP)적수평병연구기상관성.결과 백혈병조정맥염발병솔(35.3％)고우림파류조(10.8％),차이구유통계학의의(x2=7.345,P＜0.01).백혈병조중궤계성정맥염환자적외주혈WBC계수(17.4±5.48)×109/L,현저고우비정맥염환자(6.13±2.31)×109/L,차이구유통계학의의(t=11.9,P＜0.05),차WBC계수수평여정맥염급별정정상관(r=0.998,P＜0.05).이림파류조중궤계성정맥염환자적외주혈WBC계수여비정맥염환자차이무통계학의의(P＞0.05),차WBC계수수평여정맥염급별무상관관계(P＞0.05).백혈병조중정맥염환자적혈CRP(48.80±21.10)mg/L현저고우비정맥염환자(13.90±5.51) mg/L,차이구유통계학의의(t=10.4,P＜0.05),차혈CRP수평여정맥염급별정정상관(r =0.989,P＜0.05).림파류조정맥염환자CRP(37.0±7.74) mg/L현저고우비정맥염환자(12.8±5.84) mg/L,차이구유통계학의의(t=7.88,P＜0.05),단여정맥염급별무상관관계(P＞0.05).결론 재백혈병급림파류환자중,발생PICC술후궤계성정맥염환자구유교고적전신염증반응수평,제시재림상공작중대우저류환자응가강정맥염적예방급호리.
Objective To explore the incidence of PICC-caused mechanical phlebitis and the relation between the incidence and the inflammatory reaction leVel after leukemia and lymphoma patients receiVed PICC.Methods Totals of 68 leukemia patients and 37 lymphoma patients were selected.The incidence of PICCcaused mechanical phlebitis,the leVel of white blood cell (WBC) count and C-reactiVe protein (CRP) in leukemia and lymphoma patients were collected and the relation between WBC,CRP and the incidence of PICCcaused mechanical phlebitis was analysed.Results The incidence of mechanical phlebitis was 35.1％ in leukemia group high than10.8％ in lymphoma group,and the difference was statistically significant (x2 =7.345,P ＜ 0.01 ).In leukemia group,the WBC count in mechanical phlebitis patients was ( 17.4 ± 5.48) × 109/Lsignificantly higher than no mechanical phlebitis patients ( 6.13 ± 2.31 ) × 109/L,in the difference was statistically significant (t =11.9,P ＜ 0.05),and WBC count was positiVely correlated with phlebitis leVel ( r =0.989,P ＜ 0.05 ),while those was not detected in lymphoma group ( P ＞ 0.05 ).The CRP of mechanical phlebitis patients in leukemia group was(48.80 ±21.10) mg/L significantly higher (37.0 ± 7.74) mg/L in no mechanical phlebitis patients,the difference was statistically significant ( t =10.4,P ＜ 0.05 ),and CRP level was positiVely correlated with phlebitis leVel ( r =0.989,P ＜ 0.05 ).The CRP of mechanical phlebitis patients in lymphoma group was (37.0 ± 7.74) mg/L significantly higher than ( 12.8 ± 5.84 ) mg/L in no mechanical phlebitis patients,the difference was statistically significant ( t =7.88,P ＜ 0.05 ),but there was no relation between CRP leVel and phlebitis leVel (P ＞ 0.05).Conclusions In leukemia and lymphoma patients with PICC-caused mechanical phlebitis have higher systemic inflammatory reaction condition.So,it is important for those patients to enhance mechanical phlebitis preVention and nursing.