CAJ | 학술논문

目的分析高危16型和18型人乳头瘤病毒(HPV)在肛门直肠常见病变的鳞状及柱状细胞中的感染情况.方法对南京中医药大学第三附属医院全国肛肠医疗中心的肛门直肠常见病变切除的805例石蜡标本采用实时荧光定量PCR仪进行16和18两种高危型HPV DNA的分型检测.结果肛门直肠常见病变总的HPV感染阳性率为66.1％ (532/805),混合痔阳性率为82.6％(95/115),肛乳头状纤维瘤阳性率为76.5％(88/115),内痔阳性率为74.8％(86/115),肛瘘阳性率为72.2％(83/115),外痔阳性率为69.6％(80/115),肛周脓肿阳性率为47.8％ (55/115),肛裂阳性率为39.1％(45/115).结论肛门直肠常见病变中高危16型和18型HPV的感染率较高,提示肛门直肠是又一个人乳头瘤病毒的高感染区.
목적 분석고위16형화18형인유두류병독(HPV)재항문직장상견병변적린상급주상세포중적감염정황.방법 대남경중의약대학제삼부속의원전국항장의료중심적항문직장상견병변절제적805례석사표본채용실시형광정량PCR의진행16화18량충고위형HPV DNA적분형검측.결과 항문직장상견병변총적HPV감염양성솔위66.1％ (532/805),혼합치양성솔위82.6％(95/115),항유두상섬유류양성솔위76.5％(88/115),내치양성솔위74.8％(86/115),항루양성솔위72.2％(83/115),외치양성솔위69.6％(80/115),항주농종양성솔위47.8％ (55/115),항렬양성솔위39.1％(45/115).결론 항문직장상견병변중고위16형화18형HPV적감염솔교고,제시항문직장시우일개인유두류병독적고감염구.
Objective To analyze the infection condition of human papillomavirus (HPV) type 16 and 18 in the squamous cells and columnar ceils of patients with common anorecatal lesions.Methods Infections of HPV type 16 and 18 were determined with real-time fluorescent quantitative PCR in the wax-embedded surgical specimen of 805 patients with common anorectal diseases.Results The overall infection rate among 805 patients with anorecatal lesions was 66.1％(532/805).The infection rate was 82.6％(95/115) in patients with mixed hemorrhoids,76.5％(88/115) in anal papillary fibromas,74.8％(86/115) in internal hemorrhoids,72.2％(83/115) in fistulas,69.6％(80/115) in external hemorrhoids,47.8％(55/115) in anal perianal abscesses,and 39.1％(45/115) in anal fissures.Conclusion Infection rate of HPV type 16,18 in common anorectal lesions is high.