中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2011年
8期
654-658
,共5页
孙首悦%王卫庆%蒋怡然%王毅峰%叶俊娜%张曼娜%周伟%詹维伟%李小英%宁光
孫首悅%王衛慶%蔣怡然%王毅峰%葉俊娜%張曼娜%週偉%詹維偉%李小英%寧光
손수열%왕위경%장이연%왕의봉%협준나%장만나%주위%첨유위%리소영%저광
性腺功能减退症%戈那瑞林%输注泵
性腺功能減退癥%戈那瑞林%輸註泵
성선공능감퇴증%과나서림%수주빙
Hypogonadism%Gonadorelin%Infusion pumps
目的 观察微量泵脉冲输注戈那瑞林(LHRH)治疗特发性低促性腺激素性性腺功能减退症(IHH)的有效性.方法 开放、自身对照前瞻性研究.31例患者入选,分为3组:A组无脉冲型,男性23例;B组脉冲频率不足型,男性2例;C组女性6例.使用微量输液泵每90min皮下脉冲输注LHRH,治疗24周.比较治疗前后性激素和相关症状变化情况.结果 治疗24周LH峰值A组(6.92±5.66)IU/L,B组(9.55±0.98)IU/L,C组(6.93±4.52)IU/L.FSH峰值A组(7.44±3.80)IU/L,B组(12.85±12.80)IU/L,C组(7.38±4.98)IU/L;睾酮A组(3.18±1.81)ng/ml,B组(5.78±4.65)ng/ml;比治疗前明显升高(均P＜0.01).A、B两组睾丸体积均比治疗前增大.7例精液产生,6例生精.C组子宫体积增加85.4%.双侧卵巢体积增加.5例在3个月内初潮.约19.4%患者出现注射部位局部轻度不良反应.结论 微量泵脉冲输注戈那瑞林治疗IHH是有效的,但给药方法仍有可改进之处.
目的 觀察微量泵脈遲輸註戈那瑞林(LHRH)治療特髮性低促性腺激素性性腺功能減退癥(IHH)的有效性.方法 開放、自身對照前瞻性研究.31例患者入選,分為3組:A組無脈遲型,男性23例;B組脈遲頻率不足型,男性2例;C組女性6例.使用微量輸液泵每90min皮下脈遲輸註LHRH,治療24週.比較治療前後性激素和相關癥狀變化情況.結果 治療24週LH峰值A組(6.92±5.66)IU/L,B組(9.55±0.98)IU/L,C組(6.93±4.52)IU/L.FSH峰值A組(7.44±3.80)IU/L,B組(12.85±12.80)IU/L,C組(7.38±4.98)IU/L;睪酮A組(3.18±1.81)ng/ml,B組(5.78±4.65)ng/ml;比治療前明顯升高(均P＜0.01).A、B兩組睪汍體積均比治療前增大.7例精液產生,6例生精.C組子宮體積增加85.4%.雙側卵巢體積增加.5例在3箇月內初潮.約19.4%患者齣現註射部位跼部輕度不良反應.結論 微量泵脈遲輸註戈那瑞林治療IHH是有效的,但給藥方法仍有可改進之處.
목적 관찰미량빙맥충수주과나서림(LHRH)치료특발성저촉성선격소성성선공능감퇴증(IHH)적유효성.방법 개방、자신대조전첨성연구.31례환자입선,분위3조:A조무맥충형,남성23례;B조맥충빈솔불족형,남성2례;C조녀성6례.사용미량수액빙매90min피하맥충수주LHRH,치료24주.비교치료전후성격소화상관증상변화정황.결과 치료24주LH봉치A조(6.92±5.66)IU/L,B조(9.55±0.98)IU/L,C조(6.93±4.52)IU/L.FSH봉치A조(7.44±3.80)IU/L,B조(12.85±12.80)IU/L,C조(7.38±4.98)IU/L;고동A조(3.18±1.81)ng/ml,B조(5.78±4.65)ng/ml;비치료전명현승고(균P＜0.01).A、B량조고환체적균비치료전증대.7례정액산생,6례생정.C조자궁체적증가85.4%.쌍측란소체적증가.5례재3개월내초조.약19.4%환자출현주사부위국부경도불량반응.결론 미량빙맥충수주과나서림치료IHH시유효적,단급약방법잉유가개진지처.
Objective To explore the efficacy of pulse infusion of gonadorelin (LHRH) on the patients with idiopathic hypogonadotropic hypogonadism (IHH) via a micro infusion pump. Methods The protocol was designed as an open, self-controlled prospective study. 31 patients were enrolled and assigned to 3 groups: 23 males without gonadotropin-releasing hormone ( GnRH ) pulse ( group A), 2 males with GnRH pulse frequency insufficiency ( group B), and 6 females ( group C). All the subjects were admitted LHRH every 90 min via the micro infusion pump for 24 weeks. Sex hormones and related characteristics were compared before and after the treatment. Results After 24-weeks treatment, LH peak value reached ( 6. 92 ±5.66 ), ( 9. 55 ±0. 98 ), and ( 6. 93 ±4. 52 ) IU/L; and FSH peak value reached ( 7.44 ± 3. 80 ), ( 12. 85 ± 12. 80 ), and ( 7.38 ±4. 98 ) IU/L among 3 groups, respectively. The testosterone also reached ( 3.18± 1.81 ) and ( 5.78±4. 65 ) ng/ml in groups A and B ( all P＜0. 01 ). In groups A and B, the testis volumes were increased, seminal fluid production was found in 7 patients and spermatogenesis in 6 patients. In group C, uterus was enlarged 85.4%, as well as the ovaries of both sides. Menarche was reported in 5 patients. 19. 4% of the studied patients complained uncomfortable at the injection sites, all the symptoms were mild. Conclusion Pulse infusion of LHRH in IHH patients via a micro infusion pump is effective, while the medication system needs improving.
