中华麻醉学杂志
中華痳醉學雜誌
중화마취학잡지
CHINESE JOURNAL OF ANESTHESIOLOGY
2011年
1期
25-27
,共3页
饮酒%二异丙酚%剂量效应关系,药物%药物释放系统
飲酒%二異丙酚%劑量效應關繫,藥物%藥物釋放繫統
음주%이이병분%제량효응관계,약물%약물석방계통
Alcohol drinking%Propofol%Dose-response relationship,drug%Drug delivery system
目的 拟通过探讨长期饮酒对异丙酚使患者意识消失的半数有效效应室靶浓度(EC50)的影响,评价长期饮酒对异丙酚镇静效力的影响.方法 择期拟行外科手术的男性患者50例,年龄25～60岁,体重50～80kg,ASA分级Ⅰ或Ⅱ级,根据是否有长期饮酒史分为2组(n=25),对照组:日饮酒量＜25 g;长期饮酒组:日饮酒量超过45 g持续2年或2年以上.采用序贯法确定异丙酚使患者意识消失的EC50其95%可信区间,长期饮酒组和对照组异丙酚初始效应室靶浓度分别为2.0和1.5μg/ml,各相邻靶浓度之比为1.05.以睫毛反射消失及对言语指令无反应作为判断意识消失的标准.结果 长期饮酒组和对照组异丙酚使患者意识消失时的EC50及其95%可信区间分别为3.92(3.56～4.63)g/ml和2.73(2.26～3.31)μg/ml,长期饮酒组EC50高于对照组(P＜0.05).结论 长期饮酒可增加异丙酚使患者意识消失时的EC50,降低其镇静效力.
目的 擬通過探討長期飲酒對異丙酚使患者意識消失的半數有效效應室靶濃度(EC50)的影響,評價長期飲酒對異丙酚鎮靜效力的影響.方法 擇期擬行外科手術的男性患者50例,年齡25～60歲,體重50～80kg,ASA分級Ⅰ或Ⅱ級,根據是否有長期飲酒史分為2組(n=25),對照組:日飲酒量＜25 g;長期飲酒組:日飲酒量超過45 g持續2年或2年以上.採用序貫法確定異丙酚使患者意識消失的EC50其95%可信區間,長期飲酒組和對照組異丙酚初始效應室靶濃度分彆為2.0和1.5μg/ml,各相鄰靶濃度之比為1.05.以睫毛反射消失及對言語指令無反應作為判斷意識消失的標準.結果 長期飲酒組和對照組異丙酚使患者意識消失時的EC50及其95%可信區間分彆為3.92(3.56～4.63)g/ml和2.73(2.26～3.31)μg/ml,長期飲酒組EC50高于對照組(P＜0.05).結論 長期飲酒可增加異丙酚使患者意識消失時的EC50,降低其鎮靜效力.
목적 의통과탐토장기음주대이병분사환자의식소실적반수유효효응실파농도(EC50)적영향,평개장기음주대이병분진정효력적영향.방법 택기의행외과수술적남성환자50례,년령25～60세,체중50～80kg,ASA분급Ⅰ혹Ⅱ급,근거시부유장기음주사분위2조(n=25),대조조:일음주량＜25 g;장기음주조:일음주량초과45 g지속2년혹2년이상.채용서관법학정이병분사환자의식소실적EC50기95%가신구간,장기음주조화대조조이병분초시효응실파농도분별위2.0화1.5μg/ml,각상린파농도지비위1.05.이첩모반사소실급대언어지령무반응작위판단의식소실적표준.결과 장기음주조화대조조이병분사환자의식소실시적EC50급기95%가신구간분별위3.92(3.56～4.63)g/ml화2.73(2.26～3.31)μg/ml,장기음주조EC50고우대조조(P＜0.05).결론 장기음주가증가이병분사환자의식소실시적EC50,강저기진정효력.
Objective To evaluate the effect of chronic alcohol intake on the sedative potency of propofol through investigating the effect of chronic alcohol intake on the half-effective target effect-site concentration ( EC50 )of propofol required for loss of consciousness in patients. Methods Fifty male ASA Ⅰ or Ⅱ patients, aged 25-60 yr, weighing 50-80 kg, scheduled for elective surgery, were divided into 2 groups according to the history of chronic alcoholic intake ( n = 25 each): control group (alcoholic intake per day ＜ 25 g) and chronic alcoholic group (alcoholic intake per day＞45 g, lasting for 2 yr or more). The EC50 and 95% confidence interval (CI)were determined by up-and-down sequential method. The initial target effect-site concentration was 2 μg/nl in chronic alcoholic group and 1.5μg/ml in control group, and the ratio between the two successive concentrations was 1.05. Loss of consciousness was defined as loss of response to verbal command and eyelash stimulation. Results The EC50 of propofol that produced loss of consciousness was 3.92 (95 % CI 3.56-4.63 ) μg/ml in chronic alcoholic group and 2.73 (95%CI 2.26-3.31)μg/ml in control group. The EC50 of propofol was significantly higher in chronic alcoholic group than in control group ( P ＜ 0.05). Conclusion Chronic alcohol intake can increase the EC50 of propofol required to induce loss of consciousness and reduce sedative potency in patients.
