中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2012年
7期
1372-1374
,共3页
卓阳%周雪雪%庄建华%曾兴业%黄大道
卓暘%週雪雪%莊建華%曾興業%黃大道
탁양%주설설%장건화%증흥업%황대도
胰岛素%重组人表皮生长因子%复方温敏凝胶剂%溃疡愈合
胰島素%重組人錶皮生長因子%複方溫敏凝膠劑%潰瘍愈閤
이도소%중조인표피생장인자%복방온민응효제%궤양유합
Insulin%Recombinant human epidermal growth factor%Compound thermosensitive gel%Ulcer healing
目的 观察胰岛素联合重组人表皮生长因子(rhEGF)的复方温敏凝胶剂对大鼠皮肤溃疡的促愈合作用,并探讨其作用机制.方法 采用机械法在Wistar大鼠背部制备直径约1.8 cm的皮肤溃疡模型共30个,随机将溃疡分为复方温敏凝胶剂治疗组(A组)、复方溶液治疗组(B组)、空白温敏凝胶剂对照组(C组).以治疗后不同时间点各组溃疡面积愈合百分率及组织病理学检查评价修复效果.结果 治疗3d后,A、B、C3组创面的愈合百分率分别为(32.29±9.50)％、( 19.46±7.39)％、(14.81±8.62)％；治疗7d后,A、B、C3组创面的愈合百分率分别为(72.26±6.87)％、(63.40±10.91)％、(58.94±13.43)％,愈合效果A组＞B组＞C组,而治疗10、14d,3组之间比较差异无统计学意义(P＞0.05).结论 胰岛素联合rhEGF的复方温敏凝胶剂对大鼠皮肤溃疡有促愈合作用,效果优于复方溶液和空白温敏凝胶剂.
目的 觀察胰島素聯閤重組人錶皮生長因子(rhEGF)的複方溫敏凝膠劑對大鼠皮膚潰瘍的促愈閤作用,併探討其作用機製.方法 採用機械法在Wistar大鼠揹部製備直徑約1.8 cm的皮膚潰瘍模型共30箇,隨機將潰瘍分為複方溫敏凝膠劑治療組(A組)、複方溶液治療組(B組)、空白溫敏凝膠劑對照組(C組).以治療後不同時間點各組潰瘍麵積愈閤百分率及組織病理學檢查評價脩複效果.結果 治療3d後,A、B、C3組創麵的愈閤百分率分彆為(32.29±9.50)％、( 19.46±7.39)％、(14.81±8.62)％；治療7d後,A、B、C3組創麵的愈閤百分率分彆為(72.26±6.87)％、(63.40±10.91)％、(58.94±13.43)％,愈閤效果A組＞B組＞C組,而治療10、14d,3組之間比較差異無統計學意義(P＞0.05).結論 胰島素聯閤rhEGF的複方溫敏凝膠劑對大鼠皮膚潰瘍有促愈閤作用,效果優于複方溶液和空白溫敏凝膠劑.
목적 관찰이도소연합중조인표피생장인자(rhEGF)적복방온민응효제대대서피부궤양적촉유합작용,병탐토기작용궤제.방법 채용궤계법재Wistar대서배부제비직경약1.8 cm적피부궤양모형공30개,수궤장궤양분위복방온민응효제치료조(A조)、복방용액치료조(B조)、공백온민응효제대조조(C조).이치료후불동시간점각조궤양면적유합백분솔급조직병이학검사평개수복효과.결과 치료3d후,A、B、C3조창면적유합백분솔분별위(32.29±9.50)％、( 19.46±7.39)％、(14.81±8.62)％；치료7d후,A、B、C3조창면적유합백분솔분별위(72.26±6.87)％、(63.40±10.91)％、(58.94±13.43)％,유합효과A조＞B조＞C조,이치료10、14d,3조지간비교차이무통계학의의(P＞0.05).결론 이도소연합rhEGF적복방온민응효제대대서피부궤양유촉유합작용,효과우우복방용액화공백온민응효제.
Objective To investigate the effect of compound thermosensitive gel of insulin plus recombinant human epidermal growth factor (rhEGF) on the healing of skin ulcers in rats.Methods The mechanical method was used to prepare 30 skin ulcers about 1.8 cm in diameter on the back of rats.These skin ulcers were randomly divided into 3 groups:compound thermosensitive gel treatment group (group A),compound solution treatment group (group B),and blank thermosensitive gel treatment group (group C).The effect on ulcer healing was assessed by the rate of ulcer healing and histopathological changes.Results After treatment for 3 days,the rate of ulcer healing in groups A,B and C was (32.29 ± 9.50) ％,( 19.46 ±7.39)％ and ( 14.81 ±8.62)％ respec tively; After treatment for 7 days,the rate of ulcer healing in groups A,B and C was (72.26 ± 6.87 ) ％,(63.40 ± 10.91 ) ％ and ( 58.94 ± 13.43 ) ％.After treatment for 10 and 14 days,there was no statistically significant difference among three groups in the effectiveness of ulcer healing (P＞0.05 ).Conclusion Compound thermosensitive gel of insulin plus rhEGF can promote the healing of skin ulcers in rats,and its effectiveness is better than that of compound solution and blank thermosensitive gels.
