CAJ | 학술논문

[目的]为提高危重新生儿全胃肠外营养(TPN)的安全性和有效性提供依据.[方法]对2008年1月至2009年12月收治的165例住院高危早产儿的临床资料进行分析.以68例作为治疗组进行静脉营养支持,其中7～14d的29例为TPN＞1周组,14～28d的28例为TPN＞2周组.对照组97例未行静脉营养,进行微量喂养.比较静脉营养对体质量增长的影响,静脉营养并发症观察,TPN＞1周组与TPN＞2周组肝功能变化.[结果]①在积极治疗原发病基础上,TPN使早产儿体质量有明显提高.②本研究TPN不良反应有总胆汁酸升高50例,占73.52％,并随静脉营养时间延长而逐步升高.③TPN＞1周组血清胆汁酸、总胆红素、结合胆红素水平较正常时照组均有明显增高(P＜0.05),TPN＞2周组上述指标有进一步升高(P＜0.05).各实验组间丙氨酸氨基转移酶、碱性磷酸酶、总蛋白、白蛋白比较差异无统计学意义(P＞0.05).[结论]早产儿全静脉营养有其有利的、不可替代的一面,但随着时间的延长,其并发症越来越明显,而早期早产儿能耐受的微量喂养可减少TPN的并发症的发生几率.
[목적]위제고위중신생인전위장외영양(TPN)적안전성화유효성제공의거.[방법]대2008년1월지2009년12월수치적165례주원고위조산인적림상자료진행분석.이68례작위치료조진행정맥영양지지,기중7～14d적29례위TPN＞1주조,14～28d적28례위TPN＞2주조.대조조97례미행정맥영양,진행미량위양.비교정맥영양대체질량증장적영향,정맥영양병발증관찰,TPN＞1주조여TPN＞2주조간공능변화.[결과]①재적겁치료원발병기출상,TPN사조산인체질량유명현제고.②본연구TPN불량반응유총담즙산승고50례,점73.52％,병수정맥영양시간연장이축보승고.③TPN＞1주조혈청담즙산、총담홍소、결합담홍소수평교정상시조조균유명현증고(P＜0.05),TPN＞2주조상술지표유진일보승고(P＜0.05).각실험조간병안산안기전이매、감성린산매、총단백、백단백비교차이무통계학의의(P＞0.05).[결론]조산인전정맥영양유기유리적、불가체대적일면,단수착시간적연장,기병발증월래월명현,이조기조산인능내수적미량위양가감소TPN적병발증적발생궤솔.
[Objective]To provide evidence for safety and efficiency of critical neonates with total parenteral nutrition(TPN) support.[Methods]The data of 165 cases of high risk premature infants treated in municipal hospital of zaozhuang from January 2008 to December 2009 were analyzed.Sixtyeight cases in the treatment group were given intravenous nutrition.Among them,29 cases of 7-14 days were in the group of TPN＞one week,28 cases of 14-28 days were in the group of TPN above two weeks.Ninety-seven patients in the control group were given the minimal feeding,without intravenous nutrition.The effect of intravenous nutrition on weight increase,the complications and the liver function of the TPN＞one week group and TPN＞two weeks group were compared.[Results](①TPN can imcrease the weight of premature infants on the basis of treating the primary disease.②Total bile acid(TBA) increased in 50 cases,accounting for 73.52％ of TPN complications.And it increased with the intravenous nutrition time increased.③There were significant differences between the group of TPN＞one week and the control group in the serum bile acid,serum total bilirubin and serum conjugated bilirubin(P＜0.05).The results were more higher in the group of TPN＞two weeks (P＜0.05).There were no significant differences between the two groups in ALT,AKP,total protein and albumin levels (P＞0.05).[Conclusions]Total parenteral nutrition is beneficical to premature infants.But with the time increased,the complications are more and more obviouse.The minimal feeding can reduce the rate of the complications of TPN.