CAJ | 학술논문

目的探讨血清血管生成素2(Ang-2)对胰腺癌的诊断价值.方法采用酶联免疫吸附试验(ELISA)定量检测116例胰腺癌患者、50例慢性胰腺炎患者和50例健康体检者的血清Ang-2水平.结果胰腺癌、胰腺炎患者和健康体检者的血清Ang-2水平分别为(1539.0±449.3)ng/L、(1044.6±246.1)ng/L和(1075.6+228.2)ng/L,胰腺癌患者的血清Ang-2水平明显高于胰腺炎患者和健康体检者(均P<0.01),而胰腺炎患者与健康体检者的血清Ang-2水平差异无统计学意义(P>0.05).淋巴结转移和无转移患者的血清Ang-2水平分别为(1890.1±354.9)ng/L和(1212.1±224.2)ng/L(P<0.01).血清Ang-2水平诊断胰腺癌的ROC曲线下面积为0.819.结论血清Ang-2水平可以作为胰腺癌诊断的参考指标之一.
목적 탐토혈청혈관생성소2(Ang-2)대이선암적진단개치.방법 채용매련면역흡부시험(ELISA)정량검측116례이선암환자、50례만성이선염환자화50례건강체검자적혈청Ang-2수평.결과 이선암、이선염환자화건강체검자적혈청Ang-2수평분별위(1539.0±449.3)ng/L、(1044.6±246.1)ng/L화(1075.6+228.2)ng/L,이선암환자적혈청Ang-2수평명현고우이선염환자화건강체검자(균P<0.01),이이선염환자여건강체검자적혈청Ang-2수평차이무통계학의의(P>0.05).림파결전이화무전이환자적혈청Ang-2수평분별위(1890.1±354.9)ng/L화(1212.1±224.2)ng/L(P<0.01).혈청Ang-2수평진단이선암적ROC곡선하면적위0.819.결론 혈청Ang-2수평가이작위이선암진단적삼고지표지일.
Objective To evaluate the diagnostic value of serum angiopoietin-2 (Ang-2) level in pancreatic cancer patients.Methods Serum Ang-2 level was measured by enzyme-linked immunosorbent assays (ELISA) in samples from 116 patients with pancreatic cancer, 50 patients with chronic pancreatitis,and 50 normal control subjects.Results The serum Ang-2 level in patients with pancreatic cancer [( 1539.0 ± 449.3) ng/L] was significantly higher than those in patients with pancreatitis [( 1044.6 ±246.1 ) ng/L,P < 0.01] and normal control subjects [( 1075.6 ± 228.2) ng/L, P < 0.01].There was no significant difference of serum Ang-2 levels between patients with pancreatitis and normal controls.Pancreatic caner patients with lymph node metastasis had a significantly higher serum Ang-2 level[( 1890.1±354.9) ng/L]than those without metastasis [(1212.1 ±224.2) ng/L,P ＜0.01].The area under ROC curve of serum Ang-2 level for diagnosis of pancreatic cancer was 0.819.Conclusion The serum Ang-2 level can be a useful indicator for diagnosis of pancreatic cancer.