中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2012年
14期
943-947
,共5页
肺疾病,慢性阻塞性%住院病人%危险因素%合并症
肺疾病,慢性阻塞性%住院病人%危險因素%閤併癥
폐질병,만성조새성%주원병인%위험인소%합병증
Pulmonary disease,chronic obstructive%Inpatients%Risk factors%Comorbidities
目的 调查住院慢性阻塞性肺疾病(COPD)患者合并症分布情况及相关危险因素.方法 对北京大学第三医院2003年1月至2008年12月出院诊断包含有COPD的患者的临床资料进行回顾性分析,统计合并症分布情况(对反复住院的患者以最近一次住院资料为准),并对其危险因素进行Logistic多因素回归分析.结果 共495例患者出院诊断包含有COPD,363例(73.3%)合并其他疾患,前5位的合并症分别为:高血压297例(60.0%)、缺血性心脏病79例(16.0%)、恶性肿瘤54例(10.9%)、糖尿病52例(10.5%)、慢性充血性心力衰竭和血脂异常各49例(9.9%).第1秒用力呼气量占预计值百分比(FEV1%预计值)<30%、≥30%~<50%、≥50%~<80%、≥80%四组患者合并缺血性心脏病的比例分别为9.2%、12.7%、21.3%、16.5% (P=0.052),合并血脂异常的比例分别为5.3%、5.7%、10.9%、20.3% (P=0.002).体质指数<18.5、18.5~23.9、24.0~27.9、≥28.Okg/m2 4组患者合并缺血性心脏病的比例分别为13.6%、14.2%、14.6%、28.3%(P=0.051),合并血脂异常的比例分别为5.5%、5.7%、14.6%、25.O%(P=0.000).过去1年因COPD急性发作住院次数≥2次和<2次患者合并缺血性心脏病的比例分别为4.8%和24.0%(P=0.000).血清C反应蛋白水平高于第75百分位数(OR=2.371,P=0.014)、合并代谢综合征(OR=2.694,P=0.003)是COPD患者合并缺血性心脏病的危险因素.结论 不同COPD人群,合并症分布情况不同;血CRP水平高、合并代谢综合征是COPD患者合并缺血性心脏病的独立危险因素.
目的 調查住院慢性阻塞性肺疾病(COPD)患者閤併癥分佈情況及相關危險因素.方法 對北京大學第三醫院2003年1月至2008年12月齣院診斷包含有COPD的患者的臨床資料進行迴顧性分析,統計閤併癥分佈情況(對反複住院的患者以最近一次住院資料為準),併對其危險因素進行Logistic多因素迴歸分析.結果 共495例患者齣院診斷包含有COPD,363例(73.3%)閤併其他疾患,前5位的閤併癥分彆為:高血壓297例(60.0%)、缺血性心髒病79例(16.0%)、噁性腫瘤54例(10.9%)、糖尿病52例(10.5%)、慢性充血性心力衰竭和血脂異常各49例(9.9%).第1秒用力呼氣量佔預計值百分比(FEV1%預計值)<30%、≥30%~<50%、≥50%~<80%、≥80%四組患者閤併缺血性心髒病的比例分彆為9.2%、12.7%、21.3%、16.5% (P=0.052),閤併血脂異常的比例分彆為5.3%、5.7%、10.9%、20.3% (P=0.002).體質指數<18.5、18.5~23.9、24.0~27.9、≥28.Okg/m2 4組患者閤併缺血性心髒病的比例分彆為13.6%、14.2%、14.6%、28.3%(P=0.051),閤併血脂異常的比例分彆為5.5%、5.7%、14.6%、25.O%(P=0.000).過去1年因COPD急性髮作住院次數≥2次和<2次患者閤併缺血性心髒病的比例分彆為4.8%和24.0%(P=0.000).血清C反應蛋白水平高于第75百分位數(OR=2.371,P=0.014)、閤併代謝綜閤徵(OR=2.694,P=0.003)是COPD患者閤併缺血性心髒病的危險因素.結論 不同COPD人群,閤併癥分佈情況不同;血CRP水平高、閤併代謝綜閤徵是COPD患者閤併缺血性心髒病的獨立危險因素.
목적 조사주원만성조새성폐질병(COPD)환자합병증분포정황급상관위험인소.방법 대북경대학제삼의원2003년1월지2008년12월출원진단포함유COPD적환자적림상자료진행회고성분석,통계합병증분포정황(대반복주원적환자이최근일차주원자료위준),병대기위험인소진행Logistic다인소회귀분석.결과 공495례환자출원진단포함유COPD,363례(73.3%)합병기타질환,전5위적합병증분별위:고혈압297례(60.0%)、결혈성심장병79례(16.0%)、악성종류54례(10.9%)、당뇨병52례(10.5%)、만성충혈성심력쇠갈화혈지이상각49례(9.9%).제1초용력호기량점예계치백분비(FEV1%예계치)<30%、≥30%~<50%、≥50%~<80%、≥80%사조환자합병결혈성심장병적비례분별위9.2%、12.7%、21.3%、16.5% (P=0.052),합병혈지이상적비례분별위5.3%、5.7%、10.9%、20.3% (P=0.002).체질지수<18.5、18.5~23.9、24.0~27.9、≥28.Okg/m2 4조환자합병결혈성심장병적비례분별위13.6%、14.2%、14.6%、28.3%(P=0.051),합병혈지이상적비례분별위5.5%、5.7%、14.6%、25.O%(P=0.000).과거1년인COPD급성발작주원차수≥2차화<2차환자합병결혈성심장병적비례분별위4.8%화24.0%(P=0.000).혈청C반응단백수평고우제75백분위수(OR=2.371,P=0.014)、합병대사종합정(OR=2.694,P=0.003)시COPD환자합병결혈성심장병적위험인소.결론 불동COPD인군,합병증분포정황불동;혈CRP수평고、합병대사종합정시COPD환자합병결혈성심장병적독립위험인소.
Objective To explore the incidence of comorbidities in hospitalized chronic obstructive pulmonary disease (COPD) patients and influencing factors.Methods A rctrospective review of medical records was performed for 495 hospitalized COPD patients in Peking University Third Hospital from Januray 2003 to December 2008.Their commorbidities were identified and ranked in prevalence.The risk factors of commorbidities were analyzed by multivariable Logistic regression.Results The most frequent comorbidities were:hypertension (60.0%),ischemic heart disease (16.0%),malignant tumor (10.9%),diabetes mellitus (10.5%),chronic heart failure (9.9%) and dyslipidemia (9.9%).The percentage of patients with ischemic heart disease in people with FEV1% Pred<30%,30%≤FEV1% Pred<50%,50%≤FEV1% Pred<80% and FEV1% Pred≥80% were 9.2%,12.7%,21.3% and 16.5% respectively (P=0.052 ). The percentage of patients with dyslipidemia in people with FEV1% Pred<30%,30%≤FEV1% Pred<50%,50%≤FEV1% Pred<80%,FEV1% Pred ≥80% were 5.3%,5.7%,10.9% and 20.3% respectively (P=0.002).The percentage of patients with ischemic heart disease in people with body mass index (BMI) <18.5,18.5-23.9,24.0-27.9,≥28.0 kg/m2 were 13.6%,14.2%,14.6% and 28.3% respectively (P=0.051).The percentage of patients with dyslipidemia in people with BMI<18.5,18.5-23.9,24.0-27.9,≥28.0 kg/m2 were 5.5%,5.7%,14.6% and 25.0% respectively (P=0.000).The levels of C-reactive protein (CRP) were higher than the 75th percentile (OR=2.371,P=0.014),and complications with metabolic syndrome (OR=2.694,P=0.003) were independent risk factors of ischemic heart disease in COPD patients.Conclusions The incidence of comorbidities varies in different COPD populations.Higher levels of CRP and complications with metabolic syndrome are independent risk factors of ischemic heart disease in COPD patients.