CAJ | 학술논문

目的:调查通过献血途径感染人类免疫缺陷病毒(Human immunodeficiency virus,HIV)的203例患者的神经认知状况和社会生活功能.方法:横断面研究,采用神经心理成套测验和日常生活能力量表对安徽阜阳203例通过献血途径感染HIV的患者进行调查,选取198例年龄、性别和受教育年限相匹配的HIV阴性献血者为对照.神经心理成套测验包括执行功能、词语流畅、学习、记忆、精细运动、信息处理速度和工作记忆7个认知领域.以总体缺陷分≥0.5分作为认知损害的划界分.结果:HIV阳性受试总体认知功能[(45.7±5.9) vs.(49.4±6.0),P<0.01]和7个认知领域都较HIV阴性受试差.在精细运动功能方面HIV与丙型肝炎病毒(Heptitis C virus,HCV)感染存在交互作用(F=5.28,P<0.05).临床无症状期的HIV感染者和获得性免疫缺陷综合征(Acquired Immune Deficiency Syndrome,AIDS)患者认知损害率分别为29.2%和43.0%.HIV阳性受试的日常生活能力下降得分高于HIV阴性受试[(0.49±1.32 vs.(0.14±0.75),P<0.01],工作月数、个人和家庭月收入少于HIV阴性受试(P<0.01).认知损害组患者最低CD4细胞计数低于非认知损害组[(214.3±144.0) vs.(274.8±161.1),P=0.010],日常生活能力下降更明显[(0.75±1.58)vs.(0.34±1.13,) P<0.01].总体认知功能和日常生活能力下降相关(r=-0.22,P<0.01).结论:HIV感染者7个神经认知领域均有损害,合并丙型肝炎病毒感染可加重精细运动功能损害,随着疾病进展认知损害率提高;HIV感染者日常生活能力下降、职业功能和经济收入更差.最低CD4细胞计数对神经认知功能受损有一定预测作用;神经认知功能对日常生活能力下降造成一定影响,进而影响个人和家庭的经济收入.
목적:조사통과헌혈도경감염인류면역결함병독(Human immunodeficiency virus,HIV)적203례환자적신경인지상황화사회생활공능.방법:횡단면연구,채용신경심리성투측험화일상생활능역량표대안휘부양203례통과헌혈도경감염HIV적환자진행조사,선취198례년령、성별화수교육년한상필배적HIV음성헌혈자위대조.신경심리성투측험포괄집행공능、사어류창、학습、기억、정세운동、신식처리속도화공작기억7개인지영역.이총체결함분≥0.5분작위인지손해적화계분.결과:HIV양성수시총체인지공능[(45.7±5.9) vs.(49.4±6.0),P<0.01]화7개인지영역도교HIV음성수시차.재정세운동공능방면HIV여병형간염병독(Heptitis C virus,HCV)감염존재교호작용(F=5.28,P<0.05).림상무증상기적HIV감염자화획득성면역결함종합정(Acquired Immune Deficiency Syndrome,AIDS)환자인지손해솔분별위29.2%화43.0%.HIV양성수시적일상생활능력하강득분고우HIV음성수시[(0.49±1.32 vs.(0.14±0.75),P<0.01],공작월수、개인화가정월수입소우HIV음성수시(P<0.01).인지손해조환자최저CD4세포계수저우비인지손해조[(214.3±144.0) vs.(274.8±161.1),P=0.010],일상생활능력하강경명현[(0.75±1.58)vs.(0.34±1.13,) P<0.01].총체인지공능화일상생활능력하강상관(r=-0.22,P<0.01).결론:HIV감염자7개신경인지영역균유손해,합병병형간염병독감염가가중정세운동공능손해,수착질병진전인지손해솔제고;HIV감염자일상생활능력하강、직업공능화경제수입경차.최저CD4세포계수대신경인지공능수손유일정예측작용;신경인지공능대일상생활능력하강조성일정영향,진이영향개인화가정적경제수입.
Objective：To investigate the neurocognition and function of social life among human immunodeficiency virus (HIV) positive subjects infected by plasma donation.Methods:Totally 203 HIV positive subjects infected by plasma donation were recruited.Neuropsychological (NP) battery tests including executive function,verbal fluency,learning,memory,fine motor skill,speed of information processing and working memory domains were performanced among these subjects,as well as the Activity of Daily Living Scale (ADLs).And 198 HIV negative plasma donors were matched in gender,age and years of schooling.The cut-off of Global Deficit Score (GDS) was 0.5.Results：The HIV positive subjects performanced worse in global cognitive function [(45.7±5.9 vs.(49.4±6.0),P<0.01]and 7 cognitive domains than those of HIV negative subjects.HIV and HCV infection interacted on aspect of fine motor skill (F=5.28,P<0.05).The impairment rate of the subjects in asymptomatic stage and AIDS were 29.2% and 43.0% respectively.The HIV positive subjects showed more decline of ADLs scores than that of HIV negative subjects [(0.49±1.32) vs.(0.14±0.75),P<0.01].Working months,individual and family's income of HIV positive subjects were also less than that of HIV negative subjects(P<0.01).The lowest CD4 count in NP-impaired group was lower than that in non-impaired group [(214.3±144.0) vs.(274.8±161.1),P=0.01].Subjects with NP impairment reported more decline of ADLs scores [(0.75±1.58) vs.(0.34±1.13),P<0.01] than those without NP impairment.The global cognitive function scores were correlated with decline of ADLs scores (r=-0.22,P<0.01).Conclusion：HIV positive subjects are impairment on aspect of 7 cognitive domains,and co-infection of HCV can lead to more fine motor skill impairment.The more progression of disease,the higher NP impairment ratio.HIV infected subjects show decline of ADL,poorer occupational function and economical status.The lowest CD4 count may be a predictor to NP impairment.NP impairment is a factor which influenced the activity of daily living and the income of individual and family.