CAJ | 학술논문

目的探讨新型化合物Y-IP5对吗啡诱导小鼠行为敏化和条件性位置偏爱(conditioned place preference,CPP)的影响.方法测定小鼠的自发活动,观察Y-IP5对小鼠自发活动及急性给予吗啡所诱导小鼠高活动性的影响;慢性吗啡处理小鼠,建立小鼠吗啡行为敏化和CPP模型,观察Y-IP5对行为敏化形成、转化、表达及CPP形成的影响.结果单次或多次给予Y-IP5都不影响小鼠的自发活动,但能抑制急性给予吗啡所致的小鼠高活动性(P<0.05);Y-IP5本身不诱导小鼠形成行为敏化和CPP,但能抑制吗啡诱导小鼠形成行为敏化和CPP(P<0.05),但Y-IP5对吗啡诱导小鼠行为敏化的转化和表达无抑制作用.结论 Y-IP5对阿片类药物的精神依赖可能具有干预作用.
목적 탐토신형화합물Y-IP5대마배유도소서행위민화화조건성위치편애(conditioned place preference,CPP)적영향.방법 측정소서적자발활동,관찰Y-IP5대소서자발활동급급성급여마배소유도소서고활동성적영향;만성마배처리소서,건립소서마배행위민화화CPP모형,관찰Y-IP5대행위민화형성、전화、표체급CPP형성적영향.결과 단차혹다차급여Y-IP5도불영향소서적자발활동,단능억제급성급여마배소치적소서고활동성(P<0.05);Y-IP5본신불유도소서형성행위민화화CPP,단능억제마배유도소서형성행위민화화CPP(P<0.05),단Y-IP5대마배유도소서행위민화적전화화표체무억제작용.결론 Y-IP5대아편류약물적정신의뢰가능구유간예작용.
Aim To investigate the effects of Y-IP5 on morphine-induced behavioral sensitization and CPP in mice.Methods Locomotor activity was detected after Y-IP5 administration or co-administration of Y-IP5 with morphine in mice.Mice were treated with morphine to induce behavioral sensitization. Then the effects of Y-IP5 on the development, transfer and expression of morphine-induced behavioral sensitization were investigated. Mice were treated with morphine to induce CPP. Then the effect of Y-IP5 on the acquisition of morphine-induced CPP was studied.Results Y-IP5 itself didn′t influence locomotor activity of mice.Co-administration of Y-IP5 with morphine inhibited morphine-induced hyperactivity (P<0.05) and the development of morphine-induced behavioral sensitization in mice (P<0.05), however, did not influence the transfer and expression of morphine-induced behavioral sensitization.Co-administration of Y-IP5 with morphine also inhibited the acquisition of morphine-induced CPP (P<0.05).Conclusion Y-IP5 may inhibit the psychological dependence induced by morphine.