军事医学科学院院刊
軍事醫學科學院院刊
군사의학과학원원간
BULLETIN OF THE ACADEMY OF MILITARY MEDICAL SCIENCES
2010年
1期
58-60
,共3页
吴琼%卞丽红%胡晨明%杨瑛%李亚里
吳瓊%卞麗紅%鬍晨明%楊瑛%李亞裏
오경%변려홍%호신명%양영%리아리
COX-1%卵巢癌%蛋白表达
COX-1%卵巢癌%蛋白錶達
COX-1%란소암%단백표체
cyclooxygenase-1%ovarian cancer%protein expression
目的 探讨环氧化酶-1(COX-1)在卵巢癌组织中的表达及其意义.方法 应用免疫组化SP法检测37例卵巢癌和31例卵巢囊肿组织中COX-1和CA125蛋白的表达;应用ELISA法检测40例卵巢癌和31例卵巢囊肿以及60例正常体检者血清中COX-1和CA125的浓度.结果 COX-1、CA125在卵巢癌组织的表达率分别为78%和57%,在卵巢囊肿的阳性表达率仅为7%和3%;卵巢癌患者血清COX-1、CA125的阳性率分别为65%和93%.结论 COX-1蛋白表达可作为卵巢癌的辅助诊断指标.
目的 探討環氧化酶-1(COX-1)在卵巢癌組織中的錶達及其意義.方法 應用免疫組化SP法檢測37例卵巢癌和31例卵巢囊腫組織中COX-1和CA125蛋白的錶達;應用ELISA法檢測40例卵巢癌和31例卵巢囊腫以及60例正常體檢者血清中COX-1和CA125的濃度.結果 COX-1、CA125在卵巢癌組織的錶達率分彆為78%和57%,在卵巢囊腫的暘性錶達率僅為7%和3%;卵巢癌患者血清COX-1、CA125的暘性率分彆為65%和93%.結論 COX-1蛋白錶達可作為卵巢癌的輔助診斷指標.
목적 탐토배양화매-1(COX-1)재란소암조직중적표체급기의의.방법 응용면역조화SP법검측37례란소암화31례란소낭종조직중COX-1화CA125단백적표체;응용ELISA법검측40례란소암화31례란소낭종이급60례정상체검자혈청중COX-1화CA125적농도.결과 COX-1、CA125재란소암조직적표체솔분별위78%화57%,재란소낭종적양성표체솔부위7%화3%;란소암환자혈청COX-1、CA125적양성솔분별위65%화93%.결론 COX-1단백표체가작위란소암적보조진단지표.
Objective To explore the expression of cyclooxygenase-1 in ovarian cancer and its significance. Methods Expression of COX-1 and CA125 was detected by immunohistochemistry in 37 cases of ovarian cancer and 31 cases of ovarian cyst. The serum level of COX-1 and CA125 was tested in 40 cases of ovarian cancer and 31 cases of ovarian cyst and 60 healthy volunteers by ELISA. Results The positive expression of COX-1 and CA125 was 78% and 57% in ovarian cancer and 3% and 7% in ovarian cyst,respectively. The expression of COX-1 and CA125 was 65% and 93% at the serum level. Conclusion Expression of COX-1 could act as an auxiliary diagnostic criterion in ovarian carcinoma.
