CAJ | 학술논문

[目的]探讨硒中毒对猪红细胞免疫功能与自由基的影响.[方法]以15头断奶长白仔猪为试验动物,共分为2个试验组和1个对照组,检测各组猪全血硒含量、红细胞免疫功能、全血谷胱甘肽过氧化物酶(GSH-Px)活性、血浆超氧化物歧化酶(SOD)活性和血浆丙二醛(MDA)含量.[结果]猪全血硒含量明显升高,RBC-CR_1R先升高后降低,MDA先降低后升高,SOD和GSH-Px的活性降低,而RBC-ICR无明显变化.[结论] 硒中毒时降低了猪机体的抗氧化酶活性,破坏了机体氧自由基的代谢平衡,从而降低了猪红细胞的免疫功能.
[목적]탐토서중독대저홍세포면역공능여자유기적영향.[방법]이15두단내장백자저위시험동물,공분위2개시험조화1개대조조,검측각조저전혈서함량、홍세포면역공능、전혈곡광감태과양화물매(GSH-Px)활성、혈장초양화물기화매(SOD)활성화혈장병이철(MDA)함량.[결과]저전혈서함량명현승고,RBC-CR_1R선승고후강저,MDA선강저후승고,SOD화GSH-Px적활성강저,이RBC-ICR무명현변화.[결론] 서중독시강저료저궤체적항양화매활성,파배료궤체양자유기적대사평형,종이강저료저홍세포적면역공능.
[Objective] To investigate the effects of selenium toxicity on erythrocyte immune function and oxygen free radicals in pigs. [Method] All of 15 weanling Landrace pigs were selected as test animals and and divided into three group, two test group and a control group. Then the whole blood selenium levels, erythrocyte immune function, the activity of plasma superoxide dismutase (SOD) and whole blood glutathione peroxidase (GSH-Px), and the content of plasma malondialdehyde (MDA) were detected successively. [Result] In the test groups, the content of plasma selenium in whole blood was increased obviously.The rosette formation rate of RBC-CR_1R was increased at first and then decreased,but the content of MDA was decreased at first and then increased.The activity of blood GSH-Px and plasma SOD were decreased, and the rosette formation rate of RBC-IC had no obvious change. [Conclusion] Selenium toxicity can reduce the activity of antioxidant enzymes and disturb the balance of oxygen free radicals metabolism, thereby inducing erythrocyte immune function in pigs.