中国医师杂志
中國醫師雜誌
중국의사잡지
JOURNAL OF CHINESE PHYSICIAN
2011年
11期
1493-1496
,共4页
曾建平%黄河%孙智山%康松涛%彭湘洪%吴名星%吴澧源%孙建平%彭枝柳%刘颖%易文艳
曾建平%黃河%孫智山%康鬆濤%彭湘洪%吳名星%吳澧源%孫建平%彭枝柳%劉穎%易文豔
증건평%황하%손지산%강송도%팽상홍%오명성%오례원%손건평%팽지류%류영%역문염
骨髓移植%单核细胞/移植%心肌梗死/外科学/病理生理学%心室重构
骨髓移植%單覈細胞/移植%心肌梗死/外科學/病理生理學%心室重構
골수이식%단핵세포/이식%심기경사/외과학/병리생이학%심실중구
Bone marrow transplantation%Monocytes/TR%Myocardial infarction/SU/PP%Ventricular remodeling
目的 对比观察猪急性心肌梗死后早期(1周)和延期(3个月)进行的骨髓单个核细胞移植对心肌梗死后左室重构的影响.方法 前降支球囊封堵法成功建立15头猪急性心肌梗死模型,随机均分为对照组、早期移植组和延期移植组.造模1周后急性移植组行自体骨髓单个核细胞移植,对照组注射1640培养基10 ml作为对照；造模3个月后延期移植组行自体骨髓单个核细胞移植,造模后1周、造模后3个月、造模后6个月各组分别行心脏超声和SPECT检测,超声检查分析左室舒张末期内径,SPECT分析左室舒张末期容积、射血分数.结果 造模6个月后延期移植组的LVd值[(54.20±3.70) mm]低于对照组[(63.20±5.63) mm],但高于早期移植组[(47.40±1.14)mm]；EDV值[(163.00 ±6.96) ml]低于对照组[(209.40±18.69)ml],但高于早期移植组[135.40±4.93)ml]；EF值(0.25±0.02)高于对照组(0.19±0.02),但低于早期移植组(0.37±:0.02).结论 猪急性心梗3月后骨髓干细胞移植能有效抑制左室重构的进一步恶化,但其疗效不如早期移植组.
目的 對比觀察豬急性心肌梗死後早期(1週)和延期(3箇月)進行的骨髓單箇覈細胞移植對心肌梗死後左室重構的影響.方法 前降支毬囊封堵法成功建立15頭豬急性心肌梗死模型,隨機均分為對照組、早期移植組和延期移植組.造模1週後急性移植組行自體骨髓單箇覈細胞移植,對照組註射1640培養基10 ml作為對照；造模3箇月後延期移植組行自體骨髓單箇覈細胞移植,造模後1週、造模後3箇月、造模後6箇月各組分彆行心髒超聲和SPECT檢測,超聲檢查分析左室舒張末期內徑,SPECT分析左室舒張末期容積、射血分數.結果 造模6箇月後延期移植組的LVd值[(54.20±3.70) mm]低于對照組[(63.20±5.63) mm],但高于早期移植組[(47.40±1.14)mm]；EDV值[(163.00 ±6.96) ml]低于對照組[(209.40±18.69)ml],但高于早期移植組[135.40±4.93)ml]；EF值(0.25±0.02)高于對照組(0.19±0.02),但低于早期移植組(0.37±:0.02).結論 豬急性心梗3月後骨髓榦細胞移植能有效抑製左室重構的進一步噁化,但其療效不如早期移植組.
목적 대비관찰저급성심기경사후조기(1주)화연기(3개월)진행적골수단개핵세포이식대심기경사후좌실중구적영향.방법 전강지구낭봉도법성공건립15두저급성심기경사모형,수궤균분위대조조、조기이식조화연기이식조.조모1주후급성이식조행자체골수단개핵세포이식,대조조주사1640배양기10 ml작위대조；조모3개월후연기이식조행자체골수단개핵세포이식,조모후1주、조모후3개월、조모후6개월각조분별행심장초성화SPECT검측,초성검사분석좌실서장말기내경,SPECT분석좌실서장말기용적、사혈분수.결과 조모6개월후연기이식조적LVd치[(54.20±3.70) mm]저우대조조[(63.20±5.63) mm],단고우조기이식조[(47.40±1.14)mm]；EDV치[(163.00 ±6.96) ml]저우대조조[(209.40±18.69)ml],단고우조기이식조[135.40±4.93)ml]；EF치(0.25±0.02)고우대조조(0.19±0.02),단저우조기이식조(0.37±:0.02).결론 저급성심경3월후골수간세포이식능유효억제좌실중구적진일보악화,단기료효불여조기이식조.
Objective To compare the effects on left ventricular remodeling of bone marrow mononuclear cells transplantation one week and three months after acute myocardial infarction.Methods Acute myocardial infarction models were successfully established in 15 swine,which were randomly divided into three groups:placebo group,early transplantation group and late trasplantation group.One week after model had been established,early transplantation group underwent bone marrow mononuclear cells transplantation,and then so did the late trasplantation group three months after acute myocardial infarction.B-ultrasound and single photon emission computed tomography (SPECT) examinations were performed to assess the left ventricular end diastolic dimension( LVd),left ventricular end diastolic volume(EDV) and left ventricular ejection fraction(EF) before and one week,three months,six months after acute myocardial infarction.Results The LVd of late transplantation group [ (54.20:t:3.70) mm] was lower than placebo group [ (63.20 ±5.63)mm],but higher than early transplantation group [ (47.40 ± 1.14)mm].The EDV of late transplantation group [ ( 163.00 ±6.96)ml] was lower than placebo group [ (209.40 ± 18.69)ml],but higher than early transplantation group [ ( 135.40 ± 4.93 ) ml ].The EF of late transplantation group (0.25 ±0.02) was higher than placebo group (0.19 ±0.02),but lower than early transplantation group (0.37 ±0.02).Conclusions Bone marrow mononuclear cells transplantation can alleviate progressing ventricular remodeling,even it is performed three month after acute myocardial infarction,but its therapeutic effects are inferior to early transplantation's.
