国际免疫学杂志
國際免疫學雜誌
국제면역학잡지
INTERNATIONAL JOURNAL OF IMMUNOLOGY
2010年
5期
396-398
,共3页
胸腺基质淋巴细胞生成素%树突状细胞%过敏性炎症%调节性T淋巴细胞
胸腺基質淋巴細胞生成素%樹突狀細胞%過敏性炎癥%調節性T淋巴細胞
흉선기질림파세포생성소%수돌상세포%과민성염증%조절성T림파세포
Thymic stromal lymphopoietin%Dendritic cells%Allergic inflammation%Regulatory T Cells
胸腺基质淋巴细胞生成素(TSLP)是1994年被发现的一种IL-7样细胞因子,该因子对树突状细胞(DC)活化和诱导淋巴细胞及其亚群的分化、成熟有着重要的调控作用.近年来TSLP倍受关注,大量研究证实其对Th2和调节性T细胞(Treg)的分化成熟具有重要影响,并参与支气管哮喘、过敏性皮炎、过敏性鼻炎等变态反应性疾病的发生发展,因而研究其机制具有重要意义.
胸腺基質淋巴細胞生成素(TSLP)是1994年被髮現的一種IL-7樣細胞因子,該因子對樹突狀細胞(DC)活化和誘導淋巴細胞及其亞群的分化、成熟有著重要的調控作用.近年來TSLP倍受關註,大量研究證實其對Th2和調節性T細胞(Treg)的分化成熟具有重要影響,併參與支氣管哮喘、過敏性皮炎、過敏性鼻炎等變態反應性疾病的髮生髮展,因而研究其機製具有重要意義.
흉선기질림파세포생성소(TSLP)시1994년피발현적일충IL-7양세포인자,해인자대수돌상세포(DC)활화화유도림파세포급기아군적분화、성숙유착중요적조공작용.근년래TSLP배수관주,대량연구증실기대Th2화조절성T세포(Treg)적분화성숙구유중요영향,병삼여지기관효천、과민성피염、과민성비염등변태반응성질병적발생발전,인이연구기궤제구유중요의의.
Thymic stromal lymphopoietin(TSLP), identified in 1994, plays an important role in regulating the activation of dendritic cells, the differentiation and maturation of lymphocyte subsets. Up to now, great attention has been paid to TSLP. Evidence shows that TSLP has an pivotal effect on the diffferentiation and maturation of Th2 and regulatory T cells. Moreover, TSLP is related with the pathogenesis of allergic diseases,such as asthma, atopic dermatitis and allergic rhinitis, twrther studies on the mechanism of TSLP are important.
