CAJ | 학술논문

目的探讨补充外源性褪黑素对阿尔茨海默病(AD)患者睡眠和昼夜节律的影响.方法将41位受试者随机分为褪黑素组(n=24)和安慰剂组(n=17),连续10 d在22:00,分别给予褪黑素胶囊(含有8.5mg速释成分和1.5mg缓释成分的复合物)和外观与褪黑素一致的安慰剂胶囊.用Actillume腕式活动记录仪记录睡眠指数及昼夜节律指标.结果褪黑素组与安慰剂组相比,基线、治疗期问、随访期间日间与夜间的睡眠参数及昼夜节律均无差异(P>0.05).其中治疗期间,褪黑素组夜间睡眠效率(%)为(80.4±14.1);日间睡眠效率(%)为(11.9±10.5).结论服用褪黑素对AD患者睡眠质量和昼夜节律并没有影响.
목적 탐토보충외원성퇴흑소대아이자해묵병(AD)환자수면화주야절률적영향.방법 장41위수시자수궤분위퇴흑소조(n=24)화안위제조(n=17),련속10 d재22:00,분별급여퇴흑소효낭(함유8.5mg속석성분화1.5mg완석성분적복합물)화외관여퇴흑소일치적안위제효낭.용Actillume완식활동기록의기록수면지수급주야절률지표.결과 퇴흑소조여안위제조상비,기선、치료기문、수방기간일간여야간적수면삼수급주야절률균무차이(P>0.05).기중치료기간,퇴흑소조야간수면효솔(%)위(80.4±14.1);일간수면효솔(%)위(11.9±10.5).결론 복용퇴흑소대AD환자수면질량화주야절률병몰유영향.
Objective Patients with Alzheimer dementia often display poor sleep. Given that the disease is often associated with low endogenous levels of melatonin, exogenous melatonin administration may lead to improvements in sleep. Methods Randomized, placebo controlled study was carried out in 41 patients with probable Alzheimer disease. Melatonin (8. 5 mg immediate release and 1. 5 mg sustained release) (n =24) or placebo (n = 17) administered at 22:00 P. M. for 10 consecutive nights. The protocol sleep was measured continuously using actigraphy. Results There were no significant effects of melatonin,compared with placebo,on sleep and circadian rhythms. Conclusion This study failed to find a beneficial effect of exogenous melatonin.