中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2012年
10期
1449-1450
,共2页
石秀全%郭鹏%李文轩%强泽好%沈大友%吕乃昌
石秀全%郭鵬%李文軒%彊澤好%瀋大友%呂迺昌
석수전%곽붕%리문헌%강택호%침대우%려내창
胰腺炎%丹参注射液%肿瘤坏死因子α%白细胞介素6
胰腺炎%丹參註射液%腫瘤壞死因子α%白細胞介素6
이선염%단삼주사액%종류배사인자α%백세포개소6
Pancreatitis%Danshen injection%Tumor necrosis factor α%Interleukin 6
目的 观察丹参注射液对急性胰腺炎(AP)患者血清肿瘤坏死因子α( TNF-α)、白细胞介素6(IL-6)水平的影响.方法 将70例AP患者随机分为观察组和对照组,两组均采用常规抗炎、抑酸、解痉、抑制胰液分泌治疗,观察组加用丹参注射液.两组均于治疗前,治疗后1、2、4、6d分别测血清TNF-α、IL-6水平,并观察血、尿淀粉酶恢复正常所用的时间.结果 治疗后2、4、6d,观察组血清TNF-α、IL-6水平均低于对照组(均P＜0.05)；观察组血淀粉酶(AMS)恢复正常时间为(2.55±0.71)d,与对照组的(2.46±0.82)d差异无统计学意义(t =0.32,P＞0.05),而观察组尿AMS恢复正常时间为(4.30±0.72)d,短于对照组的(6.84±0.88)d(t =0.02,P＜0.05).结论 丹参注射液对降低AP患者血清TNF-α、IL-6水平,具有一定作用,对血淀粉酶无影响,具有较快降低尿淀粉酶的作用.
目的 觀察丹參註射液對急性胰腺炎(AP)患者血清腫瘤壞死因子α( TNF-α)、白細胞介素6(IL-6)水平的影響.方法 將70例AP患者隨機分為觀察組和對照組,兩組均採用常規抗炎、抑痠、解痙、抑製胰液分泌治療,觀察組加用丹參註射液.兩組均于治療前,治療後1、2、4、6d分彆測血清TNF-α、IL-6水平,併觀察血、尿澱粉酶恢複正常所用的時間.結果 治療後2、4、6d,觀察組血清TNF-α、IL-6水平均低于對照組(均P＜0.05)；觀察組血澱粉酶(AMS)恢複正常時間為(2.55±0.71)d,與對照組的(2.46±0.82)d差異無統計學意義(t =0.32,P＞0.05),而觀察組尿AMS恢複正常時間為(4.30±0.72)d,短于對照組的(6.84±0.88)d(t =0.02,P＜0.05).結論 丹參註射液對降低AP患者血清TNF-α、IL-6水平,具有一定作用,對血澱粉酶無影響,具有較快降低尿澱粉酶的作用.
목적 관찰단삼주사액대급성이선염(AP)환자혈청종류배사인자α( TNF-α)、백세포개소6(IL-6)수평적영향.방법 장70례AP환자수궤분위관찰조화대조조,량조균채용상규항염、억산、해경、억제이액분비치료,관찰조가용단삼주사액.량조균우치료전,치료후1、2、4、6d분별측혈청TNF-α、IL-6수평,병관찰혈、뇨정분매회복정상소용적시간.결과 치료후2、4、6d,관찰조혈청TNF-α、IL-6수평균저우대조조(균P＜0.05)；관찰조혈정분매(AMS)회복정상시간위(2.55±0.71)d,여대조조적(2.46±0.82)d차이무통계학의의(t =0.32,P＞0.05),이관찰조뇨AMS회복정상시간위(4.30±0.72)d,단우대조조적(6.84±0.88)d(t =0.02,P＜0.05).결론 단삼주사액대강저AP환자혈청TNF-α、IL-6수평,구유일정작용,대혈정분매무영향,구유교쾌강저뇨정분매적작용.
Objective To observe the influence of Danshen injection on the serum levels of TNF-α,IL-6 in patients with acute pancreatitis(AP).Methods 70 patients with AP were randomly divided into the experimental and control group.The two groups were given conventional anti-inflammatory,antisecretory,antispasmodic,inhibition of pancreatic secretion treatment,and the experimental group were treated with Danshen injection.Before trealment and 1,2,4,6 days after treatment,the serum TNF-α,IL-6 levels were measured in both groups.The time of blood and urine amylase(AMS) returned to normal was observed in both groups.Results 2,4,6d after treatment,the serum TNF-α,IL-6 of the observation group were lower than that of the control group( all P ＜ 0.05 ) ;The blood AMS recovery time of the observation group was ( 2.55 ± 0.71 ) d,which had no significant difference with that of the control group(2.46 +0.82)d(t =0.32,P ＞0.05 ),while urinary AMS recovery time of the observation group was (4.30 ±0.72 ) d,which was shorter than that of the control group ( 6.84 ± 0.88 ) d ( t =0.02,P ＜ 0.05 ).Conclusion Danshen injection could reduce the serum TNF-α,IL-6 levels in patients with AP,and had no effect on the serum amylase,with the trend of faster lower urinary amylase.
