CAJ | 학술논문

目的探讨颈椎前路手术对脊髓型颈椎病(CSM)患者椎间盘组织中炎性细胞因子的影响.方法 35例脊髓型颈椎病患者(CSM组)和30例颈椎外伤患者(对照组)均行颈椎前路手术治疗,观察治疗效果.采用固相分离放射免疫分析法(SPRIA)测定两组颈椎间盘组织中白细胞介素(IL)-6、IL-8、肿瘤坏死因子(TNF)－α水平.结果病程≤6个月组优良率为81.8％,病程＞6个月组优良率为38.5％,两组优良率比较差异有统计学意义(P＜0.05)；CSM患者术前JOA评分为(9.73±2.12)分,术后JOA评分为(14.21±2.52)分,术后JOA评分显著高于术前(P＜0.05)；CSM组颈椎间盘中IL-6、IL-8、TNF-α水平均显著高于对照组(P＜0.05).结论颈椎前路手术是治疗CSM的一种较有效手术方法；IL-6、IL-8、TNF-α在颈椎间盘退变和CSM发病中起重要作用.
목적 탐토경추전로수술대척수형경추병(CSM)환자추간반조직중염성세포인자적영향.방법 35례척수형경추병환자(CSM조)화30례경추외상환자(대조조)균행경추전로수술치료,관찰치료효과.채용고상분리방사면역분석법(SPRIA)측정량조경추간반조직중백세포개소(IL)-6、IL-8、종류배사인자(TNF)－α수평.결과병정≤6개월조우량솔위81.8％,병정＞6개월조우량솔위38.5％,량조우량솔비교차이유통계학의의(P＜0.05)；CSM환자술전JOA평분위(9.73±2.12)분,술후JOA평분위(14.21±2.52)분,술후JOA평분현저고우술전(P＜0.05)；CSM조경추간반중IL-6、IL-8、TNF-α수평균현저고우대조조(P＜0.05).결론 경추전로수술시치료CSM적일충교유효수술방법；IL-6、IL-8、TNF-α재경추간반퇴변화CSM발병중기중요작용.
Objective To explore the effect of anterior cervical spine surgery on inflammatory cytokines for cervical spondylotic myelopathy (CSM).Methods Thirty cases of CSM ( CSM group) and 30 cases of cervical trauma (control group) were given the anterior cervical spine surgery.The CID IL-6,IL8 and tumor necrosis factor (TNF)-α levels were detected by solid phase radioimmunoassay.The patients of CSM were followed up for the clinical efficacy and courses of disease were analyzed.Results The excellent rate in course of disease ≤ 6 months group and the course of disease ＞ 6 months group was 81.8％ and 38.5％ respectively (P ＜ 0.05 ).The preoperative and postoperative JOA scores in patients with CSM were (9.73 ±2.12) and (14.21 ±2.52) respectively (P＜0.05).The CID IL-6,IL-8 and TNF-α levels in CSM group were significantly higher than in control group (P ＜ O.05 ).Conclusion The anterior cervical spine surgery is an effective surgical treatment for CSM.The IL-6,IL-8 and TNF-α may play important roles in cervical disc degeneration and CSM.