CAJ | 학술논문

水杨酸(SA)是阿司匹林的主要有效成分,具有多种医疗疗效如美容和抗癌作用.本研究运用激光闪光光解瞬态吸收技术,考察了在266 nm激光的激励条件下水杨酸的光物理和光化学行为.实验结果表明,在266 nm的激光作用下SA可发生单光子电离,量子产率为0.21,光致电离效率较高.在细胞含氧体系中,由SA光电离生成的水合电子易与O_2结合生成超氧阴离子自由基,可杀灭癌细胞.SA光电离产生的阳离子自由基可以脱质子生成中性自由基,测得其pK_a,是2.95.用SO_4~(-·).自由基氧化SA,获得了具有390 nm特征吸收的SA~(+·),测得SO_4~(-·)氧化SA的反应速率常数为2.28×10~9 L·mol~(-1),进一步验证了SA光电离反应机理.同时发现SA可能受266nm激光激发生成激发三线态(~3SA~*),转而有可能生成单线态氧(~1O_2~*).这些结果为水杨酸作为一种潜在的抗肿瘤药物提供了依据.
수양산(SA)시아사필림적주요유효성분,구유다충의료료효여미용화항암작용.본연구운용격광섬광광해순태흡수기술,고찰료재266 nm격광적격려조건하수양산적광물리화광화학행위.실험결과표명,재266 nm적격광작용하SA가발생단광자전리,양자산솔위0.21,광치전리효솔교고.재세포함양체계중,유SA광전리생성적수합전자역여O_2결합생성초양음리자자유기,가살멸암세포.SA광전리산생적양리자자유기가이탈질자생성중성자유기,측득기pK_a,시2.95.용SO_4~(-·).자유기양화SA,획득료구유390 nm특정흡수적SA~(+·),측득SO_4~(-·)양화SA적반응속솔상수위2.28×10~9 L·mol~(-1),진일보험증료SA광전리반응궤리.동시발현SA가능수266nm격광격발생성격발삼선태(~3SA~*),전이유가능생성단선태양(~1O_2~*).저사결과위수양산작위일충잠재적항종류약물제공료의거.
Salicyfic acid (SA),the active ingredient of aspirin,is effective in various medical treatments such as cosmetology and anticaneer therapy.We investigated the photophysical and photochemical behavior of SA using 266 nm laser flash photolysis.Results demonstrate that SA Can be photoionized and photoexcited by 266 nm photons to give SA~(+·) and ~3SA~*.SA is highly photosensitive and Can be photoionized via a monophotonic process with a quantum yield of 0.21. Under the aerobic conditions we find that in Cells.hydrated electrons easily combine with oxygen to generate O_2~(-·),which can kill cancer cells.SA~(+·) can be converted into neutral radicals by deprotonation and its pK_a value is 2.95.SA also can be oxidized by SO_4~(-·) and the rate constant is 2.28×10~9 L·mol~(-1)·S~(-1),which further confirms the photoionization ability of SA.In addition,SA can be excited to ~3SA~*.which then generates ~1O_2~*.This research provides introductory theory for the potential of SA to be used as an anticancer drug.