CAJ | 학술논문

目的观察小鼠感染曼氏裂头蚴后的组织病理学改变,了解裂头蚴对组织的损害.方法从黑斑蛙体内检获裂头蚴,口服法以5条/只感染昆明小鼠,于感染后第2～10w分别处死小鼠进行组织病理学观察.结果 (1)在皮下、肌肉、肝脏、肺腔及腮腺等处发现裂头蚴,主要为皮下肌肉组织;(2)组织病理观察:肉眼观察,寄生处的组织有弥漫性淤血斑点,囊包块形成;HE镜下观察,皮下组织结构破坏,点状的脂肪组织变性、坏死,伴纤维组织增生.肺组织肺泡壁毛细血管重度扩张充血,肺泡上皮中度增生,灶性肺组织坏死.肝组织少部分肝细胞轻度胞浆疏松化,小灶性肝细胞液化性坏死伴淋巴细胞浸润取代.腮腺组织结构破坏,重度变性、坏死,伴大量急慢性炎细胞浸润并脓肿形成.结论小鼠感染裂头蚴后,多组织器官有裂头蚴寄生,其中以皮下肌肉处多见.裂头蚴寄生可引起组织不同程度的增生、变性、坏死,组织结构破坏及大量炎症细胞浸润等病理变化.
목적 관찰소서감염만씨렬두유후적조직병이학개변,료해렬두유대조직적손해.방법 종흑반와체내검획렬두유,구복법이5조/지감염곤명소서,우감염후제2～10w분별처사소서진행조직병이학관찰.결과 (1)재피하、기육、간장、폐강급시선등처발현렬두유,주요위피하기육조직;(2)조직병리관찰:육안관찰,기생처적조직유미만성어혈반점,낭포괴형성;HE경하관찰,피하조직결구파배,점상적지방조직변성、배사,반섬유조직증생.폐조직폐포벽모세혈관중도확장충혈,폐포상피중도증생,조성폐조직배사.간조직소부분간세포경도포장소송화,소조성간세포액화성배사반림파세포침윤취대.시선조직결구파배,중도변성、배사,반대량급만성염세포침윤병농종형성.결론 소서감염렬두유후,다조직기관유렬두유기생,기중이피하기육처다견.렬두유기생가인기조직불동정도적증생、변성、배사,조직결구파배급대량염증세포침윤등병리변화.
To observe the histopathological changes of mice experimentally infected with plerocercoid,mice were infected orally by plerocercoids that were collected from Rana nigromaculatus (5 strips/mouse),and were killed 2-10 weeks later to undergo the histopathological observation.Plerocercoids were found in the skin,muscle,liver,lung cavity of mice.There were diffuse congested spots and capsule formation ;the fat tissue showed severe degeneration and necrosis.In the fibrous tissues ,moderate proliferation of the enveloping adipose tissue was demonstrated.In addition,a large number of acute and chronic inflammatory cell infiltration and abscess formation could be found.It is evident that the plerocercoids parasitize mainly in the subcutaneous tissues and muscles of mice.and mice experimentally infected with plerocercoids show different degree of histopathological changes.