CAJ | 학술논문

作为大肠癌的主要化疗药物之一,奥沙利铂的应用正逐步扩展到其他肿瘤的治疗中,然而奥沙利铂相关外周神经病变却限制了其临床应用.奥沙利铂神经毒性的机制尚未明确,最新研究认为急性神经毒性是通过改变Na+短暂电导介导的；体外实验证实了丝裂原活化蛋白激酶(MAPK)在奥沙利铂慢性神经病变中的作用.多种指标可用于预测奥沙利铂相关的外周神经病变,为实现个体化药物治疗、提高化疗的连续性带来了希望.
작위대장암적주요화료약물지일,오사리박적응용정축보확전도기타종류적치료중,연이오사리박상관외주신경병변각한제료기림상응용.오사리박신경독성적궤제상미명학,최신연구인위급성신경독성시통과개변Na+단잠전도개도적；체외실험증실료사렬원활화단백격매(MAPK)재오사리박만성신경병변중적작용.다충지표가용우예측오사리박상관적외주신경병변,위실현개체화약물치료、제고화료적련속성대래료희망.
As the main drug in colorectal cancer chemotherapy,oxaliplatin is gradually infiltrated into other malignancies therapy.But oxaliplatin-induced peripheral neuropathy limits its clinical application.The mechanisms of oxaliplatin neurotoxicity are not yet clear.Recent researches show that the acute neurotoxicity of oxaliplatin is mediated through changes in Na + transient conductances.And the function of the mitogen-activated protein kinases in chronic neuropathy has already been demonstrated in vitro.Furthermore,numerous indicators can be used to predict oxaliplatin-induced peripheral neuropathy,which bring the hope for improving the continuity of chemotherapy and realizing personalized medicine therapy.