国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2012年
3期
173-175
,共3页
肝炎,乙型,慢性%抗病毒治疗%生活质量%SF-36量表
肝炎,乙型,慢性%抗病毒治療%生活質量%SF-36量錶
간염,을형,만성%항병독치료%생활질량%SF-36량표
Hepatitis B,chronic%Antiviral treatment%Life quality%SF-36 questionare
目的 评价慢性乙型肝炎患者抗病毒治疗后心理健康的状况,为临床疗效评价提供参考.方法 应用健康状况调查问卷SF-36量表,对我院2009年1月至2011年11月收治的82例慢性乙型肝炎患者(患者组)及30名健康者(对照组)进行生活质量的研究,比较两组生活质量的状况,并分析患者抗病毒治疗前后的临床客观指标和生活质量主观指标变化.结果 治疗前患者生活质量评分较健康对照组低,患者组SF-36总分为(65.1±10.7),对照组总分为(79.8±12.8),两组比较差异有统计学意义(t=6.3,P＜0.01)；治疗后,患者组生活质量有明显改善,SF-36总分为(76.3±12.5),与治疗前相比,差异有统计学意义(t=4.7,P＜0.01).患者治疗前后ALT和HBV DNA有不同程度的改善,随着临床指标的好转,患者生活质量评分也上升,提示临床指标的变化与生活质量分值的相关性.结论 慢性乙型肝炎患者的生活质量评分低于健康对照组,抗病毒治疗后生活质量的评价有助于临床疗效分析,对临床治疗的选择和决策有指导意义.
目的 評價慢性乙型肝炎患者抗病毒治療後心理健康的狀況,為臨床療效評價提供參攷.方法 應用健康狀況調查問捲SF-36量錶,對我院2009年1月至2011年11月收治的82例慢性乙型肝炎患者(患者組)及30名健康者(對照組)進行生活質量的研究,比較兩組生活質量的狀況,併分析患者抗病毒治療前後的臨床客觀指標和生活質量主觀指標變化.結果 治療前患者生活質量評分較健康對照組低,患者組SF-36總分為(65.1±10.7),對照組總分為(79.8±12.8),兩組比較差異有統計學意義(t=6.3,P＜0.01)；治療後,患者組生活質量有明顯改善,SF-36總分為(76.3±12.5),與治療前相比,差異有統計學意義(t=4.7,P＜0.01).患者治療前後ALT和HBV DNA有不同程度的改善,隨著臨床指標的好轉,患者生活質量評分也上升,提示臨床指標的變化與生活質量分值的相關性.結論 慢性乙型肝炎患者的生活質量評分低于健康對照組,抗病毒治療後生活質量的評價有助于臨床療效分析,對臨床治療的選擇和決策有指導意義.
목적 평개만성을형간염환자항병독치료후심리건강적상황,위림상료효평개제공삼고.방법 응용건강상황조사문권SF-36량표,대아원2009년1월지2011년11월수치적82례만성을형간염환자(환자조)급30명건강자(대조조)진행생활질량적연구,비교량조생활질량적상황,병분석환자항병독치료전후적림상객관지표화생활질량주관지표변화.결과 치료전환자생활질량평분교건강대조조저,환자조SF-36총분위(65.1±10.7),대조조총분위(79.8±12.8),량조비교차이유통계학의의(t=6.3,P＜0.01)；치료후,환자조생활질량유명현개선,SF-36총분위(76.3±12.5),여치료전상비,차이유통계학의의(t=4.7,P＜0.01).환자치료전후ALT화HBV DNA유불동정도적개선,수착림상지표적호전,환자생활질량평분야상승,제시림상지표적변화여생활질량분치적상관성.결론 만성을형간염환자적생활질량평분저우건강대조조,항병독치료후생활질량적평개유조우림상료효분석,대림상치료적선택화결책유지도의의.
Objective To assess the life quality of patients with chronic hepatitis after antiviral treatment,and to provide the basis of therapeutic effect assessments.Methods With the SF-36,82 patients(patient group) from January 2009 to November 2011 in our hospital and 30 healthy people(control group) were investigated.The life quality in both groups were analyzed and the change in clinical manifestation and life quality were compared.Results The scores in patients' life quality before treatment were lower than the control,the total score in patient group was (65.1 ± 10.7),and the score in the control group was ( 79.8 ± 12.8),there was a statistical difference between the two groups( t =6.3,P ＜ 0.01 ).After treatment,the total score in patient group was (76.3 ± 12.5 ),there was a statistical difference compared to the pretreatment (t =4.7,P＜0.01).The clinical index MALT,HBV DNA in patients improved after the treatments.The score of life quality of patients improved according to the clinical index suggested the relations between the two indices.Conclusions The scores of life quality in patients with chronic hepatitis B is lower than the control,the assessment of life quality is available to analyze the therapeutic effects.
