CAJ | 학술논문

目的探讨突发性耳聋患者血清抵抗素和高敏C-反应蛋白(hs-CRP)的含量变化,及其在突发性耳聋发生过程中的作用和意义.方法检测102例突发性耳聋组、35例其他疾病对照组和30例健康对照组的血清抵抗素和hs-CRP含量,并比较治疗前后血清抵抗素和hs-CRP含量的变化.结果突发性耳聋组患者治疗前血清抵抗素和hs-CRP含量较其他疾病对照组和健康对照组显著升高(P<0.01);治疗后突发性耳聋组患者抵抗素和hs-CRP含量明显降低.突发性耳聋患者血清抵抗素和hs-CRP含量呈正相关(r=0.65,P<0.01).结论血清抵抗素和hs-CRP含量的变化与突发性耳聋病情严重程度密切相关.
목적 탐토돌발성이롱환자혈청저항소화고민C-반응단백(hs-CRP)적함량변화,급기재돌발성이롱발생과정중적작용화의의.방법 검측102례돌발성이롱조、35례기타질병대조조화30례건강대조조적혈청저항소화hs-CRP함량,병비교치료전후혈청저항소화hs-CRP함량적변화.결과 돌발성이롱조환자치료전혈청저항소화hs-CRP함량교기타질병대조조화건강대조조현저승고(P<0.01);치료후돌발성이롱조환자저항소화hs-CRP함량명현강저.돌발성이롱환자혈청저항소화hs-CRP함량정정상관(r=0.65,P<0.01).결론 혈청저항소화hs-CRP함량적변화여돌발성이롱병정엄중정도밀절상관.
Objective To study the role of serum resistin and high-sensitivity C-reactive protein (hs-CRP) in idiopathic sudden sensorineural hearing loss. Methods The levels resistin and hs-CRP were determined in the 102 idiopathic sudden sensorineural hearing loss patients who were observed at two differ-ent time points: before and after treatment, and 35 patients with other neurologic diseases and 30 healthy people were used as control. Results The levels resistin and hs-CRP in serum of patients with idiopathic sudden sensorineural hearing loss were markedly higher than those in the controls (P< 0.01). The levels of resistin and ha-CRP in the patients with idiopathic sudden sensorineural hearing loss after treatment were significantly less than those before treatment. There was a correlation between serum resistin and hs-CRP in patients with idiopathic sudden senserineural hearing loss (r=0.65, P<0.01). Conclusion The levels of serum resistin and hs-CRP have instructive significance in idiopathic sudden sensorineural hearing loss treating and prognosis estimating.