CAJ | 학술논문

比较64例维持性血液透析(MHD)患者和20例健康对照者一般临床资料和临床常用血生化指标;采用乳胶颗粒增强免疫透射比浊法检测血清胱抑素C浓度,超声心动图测定心脏腔径及心功能参数.结果示MHD患者随透析时间延长,血清胱抑素C浓度逐渐增加,且左心室肥厚发生率显著增高.左心室肥厚者收缩压、左心室重量指数和血胱抑素C浓度明显高于无左心室肥厚者.胱抑素C与左心室重量指数、收缩压相关(r=0.633,0.397,均P<0.01).提示MHD患者血清胱抑素C变化可能与左心室肥厚密切相关,并可能是透析患者远期心血管并发症的影响因素.
비교64례유지성혈액투석(MHD)환자화20례건강대조자일반림상자료화림상상용혈생화지표;채용유효과립증강면역투사비탁법검측혈청광억소C농도,초성심동도측정심장강경급심공능삼수.결과 시MHD환자수투석시간연장,혈청광억소C농도축점증가,차좌심실비후발생솔현저증고.좌심실비후자수축압、좌심실중량지수화혈광억소C농도명현고우무좌심실비후자.광억소C여좌심실중량지수、수축압상관(r=0.633,0.397,균P<0.01).제시MHD환자혈청광억소C변화가능여좌심실비후밀절상관,병가능시투석환자원기심혈관병발증적영향인소.
The clinical data and routine biochemical parameters of 64 maintenance hemodialysis (MHD)patients and 20 controls were analyzed in the study.Serum cystatin C levels were detected by latex particle enhalice inununo-turbidimetry:and the cardial structure and function were assessed by echocardiography.As MHD time extended,the levels of semm cystatin C increased gradually,accompanied with high incidence of left ventricular hypertrophy(LVH).The LVH-positive patients had higher systolic blood pressure and left veHtricular mass index,and had higher serum cystatin C than tllose in LVH-negative patients.The serum cystatin C levels were positively correlated with left yentricular mass index(r=0.633,P<0.01)and systolic blood pressure(r:0.397,P<0.01).The results suggest that serum cystatin levels may be an influencing factor for long-term cardiacvascular complication in MHD patients.