CAJ | 학술논문

目的探讨PET/CT显像对非小细胞肺癌纵隔淋巴结转移的诊断价值,分析其在肺癌临床分期中的作用.方法收集我院2005年8月至2009年12月进行手术根治或纵隔淋巴结活检的非小细胞肺癌患者158例,所有患者术前均行PET/CT检查,并根据手术或纵隔镜结果进行诊断及分期.对照病理结果 ,分别计算出CT及PET/CT对诊断纵隔淋巴结转移灶的敏感性、特异性,阳性和阴性预测值及准确性.结果 158例患者通过纵隔镜活检及手术切除病理证实的淋巴结共937枚(N1、N2及N3),CT诊断的敏感性、特异性、阳性和阴性预测值分别为51.0%、76.1%、49.0%、77.6%,准确度为68.4%; PET/CT显像的敏感性、特异性、阳性和阴性预测值分别为83.7%、89.0%、77.4%和92.4%,准确度为87.3%.结论 PET/CT显示为阳性的淋巴结,有必要行纵隔镜检查,阴性者则可能不需行此项检查.
목적 탐토PET/CT현상대비소세포폐암종격림파결전이적진단개치,분석기재폐암림상분기중적작용.방법 수집아원2005년8월지2009년12월진행수술근치혹종격림파결활검적비소세포폐암환자158례,소유환자술전균행PET/CT검사,병근거수술혹종격경결과 진행진단급분기.대조병리결과 ,분별계산출CT급PET/CT대진단종격림파결전이조적민감성、특이성,양성화음성예측치급준학성.결과 158례환자통과종격경활검급수술절제병리증실적림파결공937매(N1、N2급N3),CT진단적민감성、특이성、양성화음성예측치분별위51.0%、76.1%、49.0%、77.6%,준학도위68.4%; PET/CT현상적민감성、특이성、양성화음성예측치분별위83.7%、89.0%、77.4%화92.4%,준학도위87.3%.결론 PET/CT현시위양성적림파결,유필요행종격경검사,음성자칙가능불수행차항검사.
Objective To investigate the value of positron emission tomographic-computed tomographic scalming (PET/CT) in the diagnosis of mediastinal lymph node metastasis in patients with non-small cell lung cancer and the application of PET/CT in the clinical staging of NSCLC. Methods A hundred and fifty-eight patients with NSCLC undergoing surgical resection and mediastinoscopy received preoperative examinations with PET/CT. All the patients underwent mediastinal lymph node dissection or sampling, and the pathological results were compared with the imaging findings. The diagnostic sensitivity,specificity, positive and negative predictive values, and accuracy of CT and PET/CT were compared. Results Final histology was available for 937 lymph node samples (N1, N2, and N3) from 158 patients during mediastinoscopy or surgical resection.The sensitivity, specificity, and positive and negative predictive values of CT for identifying mediastinal lymph node involvement were 51.0%, 76.1%, 49.0%, and 77.6%, respectively, with an diagnostic accuracy of 68.4%. The sensitivity, specificity, and positive and negative predictive values of PET/CT were 83.7%, 89.0%, 77.4%, and 92.4%, respectively, with a diagnostic accuracy of 87.3%. Conclusion Mediastinoscopy is essential for patients with positive findings of mediastinal lymph node involvement by PET/CT, but might not be necessary in negative patients.