中国糖尿病杂志
中國糖尿病雜誌
중국당뇨병잡지
CHINESE JOURNAL OF DIABETES
2011年
1期
41-44
,共4页
赵昉%邓小戈%苏文静%赵国宁
趙昉%鄧小戈%囌文靜%趙國寧
조방%산소과%소문정%조국저
糖尿病,2型%内皮依赖性血管舒张功能%超声%颈动脉
糖尿病,2型%內皮依賴性血管舒張功能%超聲%頸動脈
당뇨병,2형%내피의뢰성혈관서장공능%초성%경동맥
Diabetes mellitus, type 2%Endothelium-dependent vasodilation% Ultrasound% Carotid
目的 探讨2型糖尿病(T2DM)早期患者血管内皮功能的变化及其临床意义.方法 选择44例新诊断无并发症的T2DM早期患者和40名年龄、性别等匹配的正常对照者.采集空腹静脉血测定FPG、FIns、HbA1c、TC,TG、HDL-C、LDL-C、UA、NO、内皮素1(ET-1)等,并行75g葡萄糖耐量试验测定2hPG.采用高分辨率血管外彩超测定肱动脉、颈动脉的血管内径及颈动脉内膜中层厚度(IMT),以反应性充血前后血管内径变化百分比反映血管舒张功能.对IMT与各项指标的变化进行相关性分析.结果 T2DM组与对照组之间FPG、FIns、2hPG、HbA1c、TG、TC、HDL-C、LDL-C、HOMA-IR、NO、ET-1差异均有统计学意义(P＜0.05或P＜0.01),而性别、年龄、BMI、收缩压、舒张压、UA差异无统计学意义(P＞0.05).T2DM组基础血管内径、血流介导的内皮依赖性舒张功能和硝酸甘油介导的非内皮依赖性舒张功能与对照组之间差异有统计学意义(P＜0.01).基础血流在两组间差异无统计学意义(P＞0.05).不同部位IMT在不同人群中的密切相关因素是不同的.结论 T2DM早期患者就有血管内皮功能损伤,不仅存在内皮依赖性血管舒张功能障碍,而且存在非内皮依赖性血管舒张功能障碍.
目的 探討2型糖尿病(T2DM)早期患者血管內皮功能的變化及其臨床意義.方法 選擇44例新診斷無併髮癥的T2DM早期患者和40名年齡、性彆等匹配的正常對照者.採集空腹靜脈血測定FPG、FIns、HbA1c、TC,TG、HDL-C、LDL-C、UA、NO、內皮素1(ET-1)等,併行75g葡萄糖耐量試驗測定2hPG.採用高分辨率血管外綵超測定肱動脈、頸動脈的血管內徑及頸動脈內膜中層厚度(IMT),以反應性充血前後血管內徑變化百分比反映血管舒張功能.對IMT與各項指標的變化進行相關性分析.結果 T2DM組與對照組之間FPG、FIns、2hPG、HbA1c、TG、TC、HDL-C、LDL-C、HOMA-IR、NO、ET-1差異均有統計學意義(P＜0.05或P＜0.01),而性彆、年齡、BMI、收縮壓、舒張壓、UA差異無統計學意義(P＞0.05).T2DM組基礎血管內徑、血流介導的內皮依賴性舒張功能和硝痠甘油介導的非內皮依賴性舒張功能與對照組之間差異有統計學意義(P＜0.01).基礎血流在兩組間差異無統計學意義(P＞0.05).不同部位IMT在不同人群中的密切相關因素是不同的.結論 T2DM早期患者就有血管內皮功能損傷,不僅存在內皮依賴性血管舒張功能障礙,而且存在非內皮依賴性血管舒張功能障礙.
목적 탐토2형당뇨병(T2DM)조기환자혈관내피공능적변화급기림상의의.방법 선택44례신진단무병발증적T2DM조기환자화40명년령、성별등필배적정상대조자.채집공복정맥혈측정FPG、FIns、HbA1c、TC,TG、HDL-C、LDL-C、UA、NO、내피소1(ET-1)등,병행75g포도당내량시험측정2hPG.채용고분변솔혈관외채초측정굉동맥、경동맥적혈관내경급경동맥내막중층후도(IMT),이반응성충혈전후혈관내경변화백분비반영혈관서장공능.대IMT여각항지표적변화진행상관성분석.결과 T2DM조여대조조지간FPG、FIns、2hPG、HbA1c、TG、TC、HDL-C、LDL-C、HOMA-IR、NO、ET-1차이균유통계학의의(P＜0.05혹P＜0.01),이성별、년령、BMI、수축압、서장압、UA차이무통계학의의(P＞0.05).T2DM조기출혈관내경、혈류개도적내피의뢰성서장공능화초산감유개도적비내피의뢰성서장공능여대조조지간차이유통계학의의(P＜0.01).기출혈류재량조간차이무통계학의의(P＞0.05).불동부위IMT재불동인군중적밀절상관인소시불동적.결론 T2DM조기환자취유혈관내피공능손상,불부존재내피의뢰성혈관서장공능장애,이차존재비내피의뢰성혈관서장공능장애.
Objective To study the alteration of endothelium-dependent vasodilation in the early stage of type 2 diabetes mellitus (T2DM). Methods 44 T2DM patients without vascular complications (T2DM) and 40 normal subjects (NC) were recruited. Fasting plasma levels of glucose(FPG), insulin(FIns), hemoglobin A1c (HbA1c), total cholesterol(TC), triglyceride(TG), high density lipoprotein-cholesterol (HDL-C),Low density lipoprotein-cholesterol(LDL-C), uric acid(UA), nitric oxide(NO) and endothelin-1(ET-1) were measured. Oral 75g glucose tolerance test was performed. The inner diameter of brachial artery and carotid artery and the intima-media thickness (IMT) of carotid artery were assayed by a high-resolution ultrasound system before and after reactive hyperemia. Vasodilation function was calculated as percent change in brachial artery diameter before and 1 min after reactive hyperemia (endothelium-dependent), and after sublingual glyceryl- trinitrate (endothelium-independent) therapy. Results FPG, FIns, 2hPG, HbA1c, TC, TG, HDL-C, LDL-C, HOMA-IR, NO and ET-1 were significantly different between T2DM and NC groups (P<0.05 or P<0.01). There were no significant differences between the two groups in age, sex, BMI, SBP, DBP and UA(P>0.05). Flow-mediated and GNT-induced vasodilation were lower in T2DM group than in NC group (all P<0.01). Conclusion The endothelium-dependent vasodilation and the endothelium-independent vasodilation are decreased in the early stage of T2DM.
