中国医师进修杂志
中國醫師進脩雜誌
중국의사진수잡지
CHINESE JOURNAL OF POSTGRADUATES OF MEDICINE
2009年
31期
15-17
,共3页
脑梗塞%磷酸丙酮酸水合酶%C反应蛋白质%预后
腦梗塞%燐痠丙酮痠水閤酶%C反應蛋白質%預後
뇌경새%린산병동산수합매%C반응단백질%예후
Brain infarction%Phosphopyruvate hydratase%C-reactive protein%Prognosis
目的 探讨急性脑梗死患者血清神经元特异性烯醇化酶(NSE)和C反应蛋白(CRP)对其病情和预后的评估价值.方法 测定92例急性脑梗死患者(观察组)和45例健康对照者(对照组)血清NSE和CRP水平,并分析观察组NSE和CRP水平与神经功能损害程度及梗死部位的关系.结果 观察组血清NSE和CRP水平明显高于对照组(P<0.01).观察组采用美国国立卫生院卒中量表(NIHSS)评分,重型者NSE和CRP水平[(35.63±7.12)μg/L、(13.82±3.57)mg/L]显著高于轻、中型者[分别为(17.24±5.32)μg/L、(5.61±2.35)mg/L和(26.08±5.91)μg/L、(9.07±2.14)mg/L](P<0.01).不同梗死部位患者血清NSE、CRP水平比较差异无统计学意义.结论 NSE和CRP是反映脑内神经元损伤或坏死的客观指标,可作为脑梗死早期判断病情和预后的指标.
目的 探討急性腦梗死患者血清神經元特異性烯醇化酶(NSE)和C反應蛋白(CRP)對其病情和預後的評估價值.方法 測定92例急性腦梗死患者(觀察組)和45例健康對照者(對照組)血清NSE和CRP水平,併分析觀察組NSE和CRP水平與神經功能損害程度及梗死部位的關繫.結果 觀察組血清NSE和CRP水平明顯高于對照組(P<0.01).觀察組採用美國國立衛生院卒中量錶(NIHSS)評分,重型者NSE和CRP水平[(35.63±7.12)μg/L、(13.82±3.57)mg/L]顯著高于輕、中型者[分彆為(17.24±5.32)μg/L、(5.61±2.35)mg/L和(26.08±5.91)μg/L、(9.07±2.14)mg/L](P<0.01).不同梗死部位患者血清NSE、CRP水平比較差異無統計學意義.結論 NSE和CRP是反映腦內神經元損傷或壞死的客觀指標,可作為腦梗死早期判斷病情和預後的指標.
목적 탐토급성뇌경사환자혈청신경원특이성희순화매(NSE)화C반응단백(CRP)대기병정화예후적평고개치.방법 측정92례급성뇌경사환자(관찰조)화45례건강대조자(대조조)혈청NSE화CRP수평,병분석관찰조NSE화CRP수평여신경공능손해정도급경사부위적관계.결과 관찰조혈청NSE화CRP수평명현고우대조조(P<0.01).관찰조채용미국국립위생원졸중량표(NIHSS)평분,중형자NSE화CRP수평[(35.63±7.12)μg/L、(13.82±3.57)mg/L]현저고우경、중형자[분별위(17.24±5.32)μg/L、(5.61±2.35)mg/L화(26.08±5.91)μg/L、(9.07±2.14)mg/L](P<0.01).불동경사부위환자혈청NSE、CRP수평비교차이무통계학의의.결론 NSE화CRP시반영뇌내신경원손상혹배사적객관지표,가작위뇌경사조기판단병정화예후적지표.
Objective To investigate the levels of serum neuron-specific enolase (NSE) and C-reactive protein ( CRP ) in patients with acute cerebral infarction, and its value on prognosis. Methods The levels of serum NSE and CRP were compared in 92 acute cerebral infarction patients (observation group) and 45 healthy (control group). The relationship between the levels of NSE, CRP and the degree of neurological damage and infarction location were analyzed. Results The levels of serum NSE and CRP were significantly higher in observation group than those in control group (P< 0.01). In observation group, the levels of serum NSE and CRP were higher in heavy patients [ (35.63 ± 7.12) μg/L, (13.82 ± 3.57) mg/L] than those in mild or medium patients [(17.24 ± 5.32) μg/L, (5.61 ± 2.35) mg/L and (26.08 ±5.91) μg/L, (9.07 ±2.14) mg/L,respectively](P<0.01). There was no significant difference in the levels of serum NSE and CRP in different infarction location(P > 0.05 ). Conclusion The level of serum NSE and CRP is an index in reflecting the degree of neurological damage, and they can be used in evaluating patient's condition and prognosis.
