转录因子Nrf2及其靶基因与肿瘤耐药的关系
전록인자Nrf2급기파기인여종류내약적관계
Transcription factor Nrf2 and it's target genes in tumor chemoresistance
  • 万方数据
    国际肿瘤学杂志 국제종류학잡지
    JOURNAL OF INTERNATIONAL ONCOLOGY
    2009年 5期 351-355 ,共5页

    张凯茹%王燕%闰慧琴

    장개여%왕연%윤혜금

    肿瘤%核因子E2相关因子2%抗药性,肿瘤 腫瘤%覈因子E2相關因子2%抗藥性,腫瘤
    종류%핵인자E2상관인자2%항약성,종류
    Neoplasms%NF-E2-related factor 2%Drug resistance,neoplasm
    转录因子Nrf2作为抗氧化反应中的关键转录因子,可以与抗氧化反应元件ABE结合正性调节Ⅱ相解毒酶、抗氧化酶及某些药物转运泵基因等靶基因的表达,与某些肿瘤对化疗产生的耐药密切相关.有望Nrf2成为逆转肿瘤耐药的有效靶点之一.
    전록인자Nrf2작위항양화반응중적관건전록인자,가이여항양화반응원건ABE결합정성조절Ⅱ상해독매、항양화매급모사약물전운빙기인등파기인적표체,여모사종류대화료산생적내약밀절상관.유망Nrf2성위역전종류내약적유효파점지일.
    As a key transcription factor in anti-oxidant reaction, NF- E2-related factor 2 ( Nrf2 ) com-bines with ARE, then regulates the expression of detoxifying enzymes, antioxidase and some drug transport pumps. Nrf2 as well as it's target genes may be relevant to some tumor chemoresistance. Nrf2 could become aneffective target for reversing tumor chemoresistance in the near future.
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