CAJ | 학술논문

报道1例多发性Bowen病并发鳞癌.患者男,61岁,全身出现多处红褐色斑块13年.患者既往养鸡多年,双上肢经常被划伤或啄伤,部分皮疹发病前有明确的外伤史.患者体质较弱,患有多种系统性疾病,间断服药治疗.皮肤科检查:全身见40余处大小不等红褐色斑片及斑块,最小约黄豆大小,最大位于右侧锁骨区,约10 cm×4 cm,表面粗糙,覆油腻性痂皮,边界清楚,部分形状不规则.右手拇指背见一处约2 cm×2 cm大小肿物,表面有黄白色痂皮,呈砺壳状,质硬.右手拇指背肿物全切,组织病理检查:高分化鳞状细胞癌.左侧胸部红褐色斑块活检,组织病理检查为:Bowen病.我们将鳞状细胞癌皮损手术切除后植皮,余皮疹给予阿维A口服治疗,所有皮疹均明显好转,部分完全消退.
보도1례다발성Bowen병병발린암.환자남,61세,전신출현다처홍갈색반괴13년.환자기왕양계다년,쌍상지경상피화상혹탁상,부분피진발병전유명학적외상사.환자체질교약,환유다충계통성질병,간단복약치료.피부과검사:전신견40여처대소불등홍갈색반편급반괴,최소약황두대소,최대위우우측쇄골구,약10 cm×4 cm,표면조조,복유니성가피,변계청초,부분형상불규칙.우수무지배견일처약2 cm×2 cm대소종물,표면유황백색가피,정려각상,질경.우수무지배종물전절,조직병리검사:고분화린상세포암.좌측흉부홍갈색반괴활검,조직병리검사위:Bowen병.아문장린상세포암피손수술절제후식피,여피진급여아유A구복치료,소유피진균명현호전,부분완전소퇴.
A case of multiple Bowen's disease and squamous cell carcinoma is reported.A 61-year-old man presented with multiple brunneus plaques all over the body for 13 years.He was often scratched or pecked in the upper limbs during the feeding of chickens and some lesions developed with a definite history of injury.The patient suffered from several systemic diseases and took medicines intermittently.Dermatological examination revealed more than 40 brunneus patches and plaques,with the smallest lesions resembling soybeans and the largest lesions measuring 10 cm × 4 cm in size.All the lesions had a rough surface and greasy crust with a clear margin and irregular shape.There was an indurated oyster shell-like mass measuring 2 cm × 2 cm in size on the dorsum of the right thumb,with yellow-white crusts. The mass was completely resected and histopathological examination revealed a diagnosis of well differentiated squamous cell carcinoma.Histopathological examination of brunneus plaques on the left chest confirmed a diagnosis of Bowen's disease.The skin defect following resection of the squamous cell carcinoma was repaired by skin transplantation,and remaining lesions were managed with oral acitretin.Thereafter,all the lesions markedly improved and some lesions completely subsided.