中华皮肤科杂志
中華皮膚科雜誌
중화피부과잡지
Chinese Journal of Dermatology
2011年
5期
358-359
,共2页
目的探讨凋亡抑制蛋白Livin和促凋亡因子Smac在尖锐湿疣组织中的表达及意义.方法 采用免疫组化SP法检测58例尖锐湿疣组织中Livin和Smac的表达.结果尖锐湿疣组织中Livin和Smac阳性表达率分别为81.03%(47,58)、77.59%(45,58),正常人对照组Livin和Smac阳性表达率分别为25.00%(5/20)、35.00%(7/20);尖锐湿疣组织中Livin和Smac阳性表达强度多为(++)～(+++),正常人对照组多在(-)～(++).两组Livin和Smac阳性表达率及表达强度差异均具有统计学意义(P<0.05).尖锐湿疣组织中Livin和Smac表达呈正相关(r=0.373,P<0.01).结论尖锐湿疣组织中存在Livin和Smac过表达,Livin和Smac的过表达可能对尖锐湿疣的发生发展有一定作用.
目的探討凋亡抑製蛋白Livin和促凋亡因子Smac在尖銳濕疣組織中的錶達及意義.方法 採用免疫組化SP法檢測58例尖銳濕疣組織中Livin和Smac的錶達.結果尖銳濕疣組織中Livin和Smac暘性錶達率分彆為81.03%(47,58)、77.59%(45,58),正常人對照組Livin和Smac暘性錶達率分彆為25.00%(5/20)、35.00%(7/20);尖銳濕疣組織中Livin和Smac暘性錶達彊度多為(++)～(+++),正常人對照組多在(-)～(++).兩組Livin和Smac暘性錶達率及錶達彊度差異均具有統計學意義(P<0.05).尖銳濕疣組織中Livin和Smac錶達呈正相關(r=0.373,P<0.01).結論尖銳濕疣組織中存在Livin和Smac過錶達,Livin和Smac的過錶達可能對尖銳濕疣的髮生髮展有一定作用.
목적탐토조망억제단백Livin화촉조망인자Smac재첨예습우조직중적표체급의의.방법 채용면역조화SP법검측58례첨예습우조직중Livin화Smac적표체.결과첨예습우조직중Livin화Smac양성표체솔분별위81.03%(47,58)、77.59%(45,58),정상인대조조Livin화Smac양성표체솔분별위25.00%(5/20)、35.00%(7/20);첨예습우조직중Livin화Smac양성표체강도다위(++)～(+++),정상인대조조다재(-)～(++).량조Livin화Smac양성표체솔급표체강도차이균구유통계학의의(P<0.05).첨예습우조직중Livin화Smac표체정정상관(r=0.373,P<0.01).결론첨예습우조직중존재Livin화Smac과표체,Livin화Smac적과표체가능대첨예습우적발생발전유일정작용.
Objective To explore the expressions of livin and Smac in condyloma acuminatum (CA) tissue and their roles. Methods The expressions of Livin and Smac were analyzed by immunocytochemical staining with streptavidin-peroxidase (SP) in tissue specimens from the lesions of 58 patients with CA and foreskin of 20 normal human controls. Results The detection rates of Livin and Smac were 81.03% (47/58) and 77.59% (45/58) in CA lesions, respectively, compared to 25.00% (5/20) and 35.00% (7/20) in the controls, respectively. The expressions of Livin and Smac varied from positive (++) to strongly positive (+++) in CA lesions, and from negative (-) to positive (++) in the controls (both P< 0.05). A positive correlation was found between the expression of Livin and Smac in CA lesions (r = 0.373, P < 0.01). Conclusion There is an over- expression of Livin and Smac in CA tissue, which may be involved in the occurrence and development of CA.
