中华实验和临床病毒学杂志
中華實驗和臨床病毒學雜誌
중화실험화림상병독학잡지
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL VIROLOGY
2010年
3期
184-186
,共3页
肝炎,乙型,慢性%肝炎e抗原,乙型%DNA%肝炎病毒属%组织病理学
肝炎,乙型,慢性%肝炎e抗原,乙型%DNA%肝炎病毒屬%組織病理學
간염,을형,만성%간염e항원,을형%DNA%간염병독속%조직병이학
Hepatitis B,chronic%Hepaitis B e antigens%DNA%Hepatitis viruses%Histopathology
目的 探讨HBeAg阴性慢性乙型肝炎患者血清HBV DNA水平与肝组织损害的关系.方法 以HBeAg阳性慢性乙型肝炎病例为对照,回顾分析HBeAg阴性慢性乙型肝炎患者血清HBVDNA水平与肝组织病理炎症分级、纤维化分期之间的关系.结果 HBeAg阴性与阳性组HBV DNA 平均含量分别为(5.38±1.27)log10拷贝/ml和(6.80±1.18)log10拷贝/ml,差异有统计学意义(P<0.01).与HBeAg阳性组比较,HBeAg阴性组肝组织炎症分级及纤维化分期较高(P<0.01).HBeAg 阴性患者HBV DNA水平与肝组织炎症分级及纤维化分期呈正相关(P<0.01).结论 HBeAg阴性慢性乙型肝炎病毒载量低,乙肝病毒载量与肝损害呈正相关.
目的 探討HBeAg陰性慢性乙型肝炎患者血清HBV DNA水平與肝組織損害的關繫.方法 以HBeAg暘性慢性乙型肝炎病例為對照,迴顧分析HBeAg陰性慢性乙型肝炎患者血清HBVDNA水平與肝組織病理炎癥分級、纖維化分期之間的關繫.結果 HBeAg陰性與暘性組HBV DNA 平均含量分彆為(5.38±1.27)log10拷貝/ml和(6.80±1.18)log10拷貝/ml,差異有統計學意義(P<0.01).與HBeAg暘性組比較,HBeAg陰性組肝組織炎癥分級及纖維化分期較高(P<0.01).HBeAg 陰性患者HBV DNA水平與肝組織炎癥分級及纖維化分期呈正相關(P<0.01).結論 HBeAg陰性慢性乙型肝炎病毒載量低,乙肝病毒載量與肝損害呈正相關.
목적 탐토HBeAg음성만성을형간염환자혈청HBV DNA수평여간조직손해적관계.방법 이HBeAg양성만성을형간염병례위대조,회고분석HBeAg음성만성을형간염환자혈청HBVDNA수평여간조직병리염증분급、섬유화분기지간적관계.결과 HBeAg음성여양성조HBV DNA 평균함량분별위(5.38±1.27)log10고패/ml화(6.80±1.18)log10고패/ml,차이유통계학의의(P<0.01).여HBeAg양성조비교,HBeAg음성조간조직염증분급급섬유화분기교고(P<0.01).HBeAg 음성환자HBV DNA수평여간조직염증분급급섬유화분기정정상관(P<0.01).결론 HBeAg음성만성을형간염병독재량저,을간병독재량여간손해정정상관.
Objective To investigate the relationship between serum HBV DNA loads and liver histology damage in the patients with HBeAg-negative chronic hepatitis B.Methods The retrospective study was performed.The 514 patients were divided into two groups according to the HBeAg status and the HBeAg positive group was as control.The relationship among HBV DNA loads,live histological inflammation grades and fibrosis stages was analyzed.Results The HBV DNA loads in HBeAg-negative group and HBeAg-positive group were(5.38±1.27)log10 copies/ml and(6.80±1.18)log10 copies/ml respectively(P<0.001).The inflammation grades and fibrosis stages of liver tissues in HBeAg-negative group were all significantly higher than those in HBeAg-positive group(P<0.001).In HBeAg-negative group,HBV DNA loads displayed a positive correlation with the inflammation grades and fibrosis stages of liver tissues(P<0.001).Conclusion In the patients with HBeAg-negative chronic hepatitis B,HBV viral loads are lower than those with HBeAg-positive chronic hepatitis B,and HBV viral loads display a positive correlation with liver the inflammation grades and fibrosis stages of liver tissues.
