CAJ | 학술논문

目的研究肝移植受者早期口服霉酚酸(免疫抑制剂)药代动力学与药效学的相关性.方法 20例肝移植受者口服霉酚酸酯前、后,用酶增强免疫法测定患者血浆霉酚酸浓度.服药前(0 h)及服药后1,2 h,用患者血清处理人急性淋巴细胞白血病T淋巴(CEM)细胞,检测CEM细胞的增殖情况.结果口服霉酚酸酯前,CEM细胞增殖率显著高于服药后1,2 h(P<0.05);服药后1,2 h霉酚酸浓度与相应的CEM细胞增殖率呈负相关(P<0.05).结论肝移植受者口服霉酚酸酯后,血清对CEM细胞的增殖产生显著抑制作用,其作用和霉酚酸浓度呈显著负相关.
목적 연구간이식수자조기구복매분산(면역억제제)약대동역학여약효학적상관성.방법 20례간이식수자구복매분산지전、후,용매증강면역법측정환자혈장매분산농도.복약전(0 h)급복약후1,2 h,용환자혈청처리인급성림파세포백혈병T림파(CEM)세포,검측CEM세포적증식정황.결과 구복매분산지전,CEM세포증식솔현저고우복약후1,2 h(P<0.05);복약후1,2 h매분산농도여상응적CEM세포증식솔정부상관(P<0.05).결론 간이식수자구복매분산지후,혈청대CEM세포적증식산생현저억제작용,기작용화매분산농도정현저부상관.
Objective To investigate the relationship between pharmacokinetics and pharmadynamics of mycophenolic acid(MPA)in liver transplant recipients.Methods Plasma MPA concentration were determined EMIT method before MMF dose and after dosing in 20 liver transplant patients received mycophenolate mofetil(MMF).The inhibitory capacity of serum MPA on proliferation of CEM cells was also monitored at 0,1 h and 2 h.Results The rate of proliferation of CEM cells before MMF administration was higher significantly than those at 1 h and 2 h after dosing (P<0.05).The concentrations of MPA at 1 h and 2 h were conversely related with the rate of proliferation of CEM cells(P<0.05).Conclusion After MMF dose,the inhibitory capacity of serum MPA on proliferation of CEM cells was enhanced significantly.This effect was related greatly to MPA concentrations.