CAJ | 학술논문

人生长激素是由腺垂体分泌的由191个氨基酸残基组成的直链多肽,它可以直接或通过胰岛素样生长因子间接地对生长和代谢发挥作用,既往主要用于儿童生长激素缺乏症的治疗.随着预期寿命的延长,人们越来越重视生活质量的提高,各种抗衰老药物不断出现,根据衰老学说之一的神经内分泌衰竭学说,生长激素近来被用于抗衰老治疗.在成人,生长激素可增加去脂肪体重,增加骨密度,改善生活质量.本文就生长激素的一般理化特性和其在健康老年人群中抗衰老的作用作一综述.
인생장격소시유선수체분비적유191개안기산잔기조성적직련다태,타가이직접혹통과이도소양생장인자간접지대생장화대사발휘작용,기왕주요용우인동생장격소결핍증적치료.수착예기수명적연장,인문월래월중시생활질량적제고,각충항쇠로약물불단출현,근거쇠노학설지일적신경내분비쇠갈학설,생장격소근래피용우항쇠로치료.재성인,생장격소가증가거지방체중,증가골밀도,개선생활질량.본문취생장격소적일반이화특성화기재건강노년인군중항쇠로적작용작일종술.
Human growth hormone is secreted by pituitary and is composed of 191 amino acid,which plays a role directly or through insulin-like growth factor indirectly in the growth and metabolism, mainly used in the treatment of child with growth hormone deficiency formerly. With the increase in life expectancy,attention to improve the quality of life is increased, and all kinds of anti-aging drugs emerge. According to neuroendocrine failure theory,growth hormone has been used for anti-aging treatment. In adults the success criteria are metabolic parameters, the increase of non-fatty body mass, increase of bone density and improvement of subjective quality of life. This article will summarize the general physical and chemical properties of growth hormone and its anti-aging effects in healthy older age groups.