CAJ | 학술논문

目的应用实时心肌超声造影评价2型糖尿病患者静息状态下的心肌微循环灌注特点.方法选取临床确诊的2型糖尿病患者13例为病例组,12例健康成人为对照组.经肘正中静脉注射SonoVue混悬液,采用GE Vivid 7 Dimension超声诊断仪实时心肌造影程序同步观察心尖四腔、两腔及左室长轴观的心肌内造影剂充填过程.存取上述切面闪烁成像前3个心动周期及闪烁后达稳定状态约15个心动周期的造影剂再充填动态图像,供脱机分析.结果静息状态下2型糖尿病患者心肌灌注超声造影的平台期信号强度(A)值、曲线上升斜率(k)值、A×k值均较对照组明显减低(A:6.46±1.60对6.81±1.53,P＜0.05;k:1.04±0.39对1.28±0.31,P＜0.01;A×k:6.55±2.72对8.78±3.16,P＜0.01).结论心肌超声造影可评价2型糖尿病患者心肌微循环灌注的早期改变,为糖尿病心肌病的早期诊断和治疗提供重要参考.
목적 응용실시심기초성조영평개2형당뇨병환자정식상태하적심기미순배관주특점.방법 선취림상학진적2형당뇨병환자13례위병례조,12례건강성인위대조조.경주정중정맥주사SonoVue혼현액,채용GE Vivid 7 Dimension초성진단의실시심기조영정서동보관찰심첨사강、량강급좌실장축관적심기내조영제충전과정.존취상술절면섬삭성상전3개심동주기급섬삭후체은정상태약15개심동주기적조영제재충전동태도상,공탈궤분석.결과 정식상태하2형당뇨병환자심기관주초성조영적평태기신호강도(A)치、곡선상승사솔(k)치、A×k치균교대조조명현감저(A:6.46±1.60대6.81±1.53,P＜0.05;k:1.04±0.39대1.28±0.31,P＜0.01;A×k:6.55±2.72대8.78±3.16,P＜0.01).결론 심기초성조영가평개2형당뇨병환자심기미순배관주적조기개변,위당뇨병심기병적조기진단화치료제공중요삼고.
Objective To explore the characteristics of resting myocardial perfusion of type 2 diabetes mellitus(T2DM) by real-time myocardial contrast echocardiography(RT-MCE). Methods Thirteen patients with T2DM and 12 in control were enrolled in the study. RT-MCE was performed using a continuous infusion of SonoVue with vena mediana in elbow. Images of left ventricle filled with contrast were acquired from apical 4-, 2-chamber and long axis views with real-time myocardial contrast mode of GE Vivid 7 Dimension system. All above images were captured in continuous 3 cardiac cycles before "flash" ,and then 15 cardiac cycles after "flash". All clips were stored for off-line analysis. Results In quiescent condition, there were significant decrease on indices of A,k and A × k in patients compared with control group (A:6.46 ±1.60 vs 6.81 ± 1.53, P ＜0.05;k:1.04 ± 0.39 vs 1.28 ± 0.31*, P ＜0.01;A× k:6.55 ± 2.72 vs 8.78 ±3.16, P ＜ 0.01, respectively). Conclusions RT-MCE could evaluate the early change of myocardial perfusion in T2DM patients and offers important reference for clinical diagnosis and treatment.