中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2011年
3期
208-211
,共4页
结直肠肿瘤%腺瘤%危险因素%肥胖症
結直腸腫瘤%腺瘤%危險因素%肥胖癥
결직장종류%선류%위험인소%비반증
Colorectal neoplasms%Adenoma%Risk factors%Obesity
目的 探讨结直肠腺瘤患病的危险因素.方法 选择健康查体的1260人为研究对象,进行生活方式的问卷调查后测量身高、体重、腰围和血压,抽空腹血检测血糖、总胆固醇、甘油三酯、HDL-C和LDL-C;超声检查判断有无脂肪肝,最后完成结肠镜检查.采用x2检验行单因素分析,用Logistic多元回归分析评价结直肠腺瘤和各种危险因素的联系程度.结果 男性、高龄(≥55岁)、吸烟、体力活动少、腹型肥胖、空腹血糖高和脂肪肝人群结直肠腺瘤患病率明显增高(x2=4.355、11.549、4.440、4.608、6.211、4.510、4.156,P均＜0.05),其中男性(OR:1.61,可信区间:1.13～2.57)、高龄(OR:4.41,可信区间:3.32～10.27)和腹型肥胖(OR:1.75,可信区间:1.21～2.86)是结直肠腺瘤的独立危险因素.对于55岁以上人群,不同性别、是否腹型肥胖与结直肠腺瘤患病差异无统计学意义(x2=1.139、3.413,P均＞0.05).结论 结直肠腺瘤与腹型肥胖、高龄和男性密切相关,但是腹型肥胖和性别对结直肠腺瘤的影响在55岁以上人群中降低,避免腹型肥胖对于55岁以下人群预防结直肠腺瘤尤其重要.
目的 探討結直腸腺瘤患病的危險因素.方法 選擇健康查體的1260人為研究對象,進行生活方式的問捲調查後測量身高、體重、腰圍和血壓,抽空腹血檢測血糖、總膽固醇、甘油三酯、HDL-C和LDL-C;超聲檢查判斷有無脂肪肝,最後完成結腸鏡檢查.採用x2檢驗行單因素分析,用Logistic多元迴歸分析評價結直腸腺瘤和各種危險因素的聯繫程度.結果 男性、高齡(≥55歲)、吸煙、體力活動少、腹型肥胖、空腹血糖高和脂肪肝人群結直腸腺瘤患病率明顯增高(x2=4.355、11.549、4.440、4.608、6.211、4.510、4.156,P均＜0.05),其中男性(OR:1.61,可信區間:1.13～2.57)、高齡(OR:4.41,可信區間:3.32～10.27)和腹型肥胖(OR:1.75,可信區間:1.21～2.86)是結直腸腺瘤的獨立危險因素.對于55歲以上人群,不同性彆、是否腹型肥胖與結直腸腺瘤患病差異無統計學意義(x2=1.139、3.413,P均＞0.05).結論 結直腸腺瘤與腹型肥胖、高齡和男性密切相關,但是腹型肥胖和性彆對結直腸腺瘤的影響在55歲以上人群中降低,避免腹型肥胖對于55歲以下人群預防結直腸腺瘤尤其重要.
목적 탐토결직장선류환병적위험인소.방법 선택건강사체적1260인위연구대상,진행생활방식적문권조사후측량신고、체중、요위화혈압,추공복혈검측혈당、총담고순、감유삼지、HDL-C화LDL-C;초성검사판단유무지방간,최후완성결장경검사.채용x2검험행단인소분석,용Logistic다원회귀분석평개결직장선류화각충위험인소적련계정도.결과 남성、고령(≥55세)、흡연、체력활동소、복형비반、공복혈당고화지방간인군결직장선류환병솔명현증고(x2=4.355、11.549、4.440、4.608、6.211、4.510、4.156,P균＜0.05),기중남성(OR:1.61,가신구간:1.13～2.57)、고령(OR:4.41,가신구간:3.32～10.27)화복형비반(OR:1.75,가신구간:1.21～2.86)시결직장선류적독립위험인소.대우55세이상인군,불동성별、시부복형비반여결직장선류환병차이무통계학의의(x2=1.139、3.413,P균＞0.05).결론 결직장선류여복형비반、고령화남성밀절상관,단시복형비반화성별대결직장선류적영향재55세이상인군중강저,피면복형비반대우55세이하인군예방결직장선류우기중요.
Objective To investigate risk factors for colorectal adenoma. Methods 1260 subjects who received health check-ups were included. A questionnaire on life style was answered and anthropometric measurements including height, weight, waist circumference and blood pressure were taken.Fasting venous blood was obtained and fasting plasma glucose, total cholesterol, triglycerides(TG), highdensity lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were measured.Fatty liver was diagnosed by ultrasonography. Colonoscopy was performed on each subject. Categorical data were compared using Pearson's chi-squared test, and multivariate logistic regression analysis was used to estimate the strength of association between the colorectal adenoma and various factors. Results The frequency of colorectal adenoma was significantly higher among males, older patients( ≥55 years), current smokers and subjects with less physical activity, abdominal obesity, fasting hyperglycemia or fatty liver (x2 =4.355, 11.549, 4.440, 4.608, 6.211, 4.510, 4.156, P＜0. 05). Male sex (OR: 1.61,CI:1.13 -2. 57), old age (OR: 4.41,CI:3.32- 10.27)and abdominal obesity (OR: 1.75,CI:1.21 -2.86)were independent risk factors for colorectal adenoma. However, the frequency of colorectal adenoma was not different in subjects above 55 years old according to gender and abdominal obesity( x2 = 1. 139, 3. 413 ,P ＞0. 05 ). Conclusions Abdominal obesity, old age and male sex were significantly associated with colorectal adenoma. However, the effect of abdominal obesity and male sex on the development of colorectal adenoma is less significant in subjects above 55 years of age. It is especially important for people under 55 years old to prevent colorectal adenoma by avoiding abdominal obesity.
