中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2012年
9期
895-898
,共4页
陈继锁%杨玉霞%胡祥华%陈庆%于雷
陳繼鎖%楊玉霞%鬍祥華%陳慶%于雷
진계쇄%양옥하%호상화%진경%우뢰
质子%光子%放射治疗%脊索瘤
質子%光子%放射治療%脊索瘤
질자%광자%방사치료%척색류
Proton%Photon%Radiotherapy%Chordoma
目的 比较利用质子与光子进行立体定向放射治疗颅底脊索瘤的疗效. 方法 淄博万杰肿瘤医院神经外科自2004年11月至2008年11月应用质子与光子进行立体定向放射治疗经病理证实的颅底脊索瘤患者57例,其中采用质子放射治疗(质子组)31例,光子放射治疗(光子组)26例.回顾性分析57例患者的临床资料并比较2组患者治疗后近期及中期的疗效. 结果 2组患者治疗后6个月、12个月临床症状缓解率的差异均无统计学意义(x2=0.057,P=0.812;x2=2.144,P=0.143);2组患者无瘤进展生存率、总生存率比较差异均有统计学意义(x2=15.571,P=0.000;x2=20.232,P=0.000).质子组患者治疗后无瘤进展生存率、总生存率均高于光子组. 结论 利用质子放射治疗颅底脊索瘤疗效优于光子放射治疗,尤其对于放射治疗后复发的脊索瘤有明显优势.
目的 比較利用質子與光子進行立體定嚮放射治療顱底脊索瘤的療效. 方法 淄博萬傑腫瘤醫院神經外科自2004年11月至2008年11月應用質子與光子進行立體定嚮放射治療經病理證實的顱底脊索瘤患者57例,其中採用質子放射治療(質子組)31例,光子放射治療(光子組)26例.迴顧性分析57例患者的臨床資料併比較2組患者治療後近期及中期的療效. 結果 2組患者治療後6箇月、12箇月臨床癥狀緩解率的差異均無統計學意義(x2=0.057,P=0.812;x2=2.144,P=0.143);2組患者無瘤進展生存率、總生存率比較差異均有統計學意義(x2=15.571,P=0.000;x2=20.232,P=0.000).質子組患者治療後無瘤進展生存率、總生存率均高于光子組. 結論 利用質子放射治療顱底脊索瘤療效優于光子放射治療,尤其對于放射治療後複髮的脊索瘤有明顯優勢.
목적 비교이용질자여광자진행입체정향방사치료로저척색류적료효. 방법 치박만걸종류의원신경외과자2004년11월지2008년11월응용질자여광자진행입체정향방사치료경병리증실적로저척색류환자57례,기중채용질자방사치료(질자조)31례,광자방사치료(광자조)26례.회고성분석57례환자적림상자료병비교2조환자치료후근기급중기적료효. 결과 2조환자치료후6개월、12개월림상증상완해솔적차이균무통계학의의(x2=0.057,P=0.812;x2=2.144,P=0.143);2조환자무류진전생존솔、총생존솔비교차이균유통계학의의(x2=15.571,P=0.000;x2=20.232,P=0.000).질자조환자치료후무류진전생존솔、총생존솔균고우광자조. 결론 이용질자방사치료로저척색류료효우우광자방사치료,우기대우방사치료후복발적척색류유명현우세.
Objective To compare the efficacy of proton radiotherapy and photon radiotherapy for chordomas in the skull base. Methods A retrospective study was performed on the clinical data of 57 patients underwent stereotactic radiotherapy of their chordomas in the skull base; these patients were divided into proton radiotherapy group (n=31,treated with proton) and photon radiotherapy group (n=26,underwent photon radiation therapy).The efficacy was reviewed comparatively. Results Fifty-seven patients were followed up for 6-76 months in clinical symptoms and 6-72 months in imaging.The clinical symptom relief rate at 6 and 12 months after the treatment showed no significant difference between the 2 groups (x2=0.057,P=0.812; x2.144,P=0.143),while the progression-free survival and the overall survival showed significant difference between the 2 groups (x2=15.571,P=0.000; x20.232,P=-0.000).The proton radiotherapy group was superior to the photon radiotherapy group in total survival rate and relapse-free survival rate at 3 and 5 years after treatment (P＜0.05). Conclusion Proton radiotherapy is better than photon radiotherapy in the treatment of chordomas in the skull base; furthermore, proton radiotherapy has its obvious advantage for patients having relapsed chordomas after radiation therapy.
