中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2004年
21期
4194-4195
,共2页
李绍生%李兰荪%郭文仪%程何祥%张莉莉%苏德兴
李紹生%李蘭蓀%郭文儀%程何祥%張莉莉%囌德興
리소생%리란손%곽문의%정하상%장리리%소덕흥
冠状动脉疾病/流行病学%载脂蛋白E类%基因
冠狀動脈疾病/流行病學%載脂蛋白E類%基因
관상동맥질병/류행병학%재지단백E류%기인
目的:研究在男性ApoE的基因多态性与冠心病严重程度的关系.方法:采用病例-病例对照的设计方法,对经选择性冠状动脉造影证实为冠心病的108例男性患者应用聚合酶链反应技术确定ApoE的基因型,分析比较ApoE的基因多态性与病情的关系.结果:E2/2,E2/3,E2/4,E3/3,E3/4和E4/4基因型分别占1.85%,10.19%,5.6%,39.81%,37.04%,5.6%,ε2,ε3和ε4等位基因频率分别为9.72%,63.43%和26.85%.E3基因型的HDL水平明显高于E2(P=0.005).E4基因型患者的病变最长长度明显长于E2基因型者(P=0.023),病变积分E4基因型者明显大于E2,E3者(P均=0.014).多重回归分析显示病变积分与病变支数、范围及基因型明显相关(b=8.118,10.356,5.187;P=0.002,0.020,0.056),Logistic回归分析显示舒张压、胆固醇浓度、三酰甘油浓度、HDL-C浓度和病变积分与基因型明显相关(b=0.079,0.893,-1.014,-3.413,0.049;P=0.033,0.032,0.027,0.040,0.039).结论:男性冠心病患者ApoE的基因多态性影响血脂代谢和病情,与疾病严重程度密切相关.
目的:研究在男性ApoE的基因多態性與冠心病嚴重程度的關繫.方法:採用病例-病例對照的設計方法,對經選擇性冠狀動脈造影證實為冠心病的108例男性患者應用聚閤酶鏈反應技術確定ApoE的基因型,分析比較ApoE的基因多態性與病情的關繫.結果:E2/2,E2/3,E2/4,E3/3,E3/4和E4/4基因型分彆佔1.85%,10.19%,5.6%,39.81%,37.04%,5.6%,ε2,ε3和ε4等位基因頻率分彆為9.72%,63.43%和26.85%.E3基因型的HDL水平明顯高于E2(P=0.005).E4基因型患者的病變最長長度明顯長于E2基因型者(P=0.023),病變積分E4基因型者明顯大于E2,E3者(P均=0.014).多重迴歸分析顯示病變積分與病變支數、範圍及基因型明顯相關(b=8.118,10.356,5.187;P=0.002,0.020,0.056),Logistic迴歸分析顯示舒張壓、膽固醇濃度、三酰甘油濃度、HDL-C濃度和病變積分與基因型明顯相關(b=0.079,0.893,-1.014,-3.413,0.049;P=0.033,0.032,0.027,0.040,0.039).結論:男性冠心病患者ApoE的基因多態性影響血脂代謝和病情,與疾病嚴重程度密切相關.
목적:연구재남성ApoE적기인다태성여관심병엄중정도적관계.방법:채용병례-병례대조적설계방법,대경선택성관상동맥조영증실위관심병적108례남성환자응용취합매련반응기술학정ApoE적기인형,분석비교ApoE적기인다태성여병정적관계.결과:E2/2,E2/3,E2/4,E3/3,E3/4화E4/4기인형분별점1.85%,10.19%,5.6%,39.81%,37.04%,5.6%,ε2,ε3화ε4등위기인빈솔분별위9.72%,63.43%화26.85%.E3기인형적HDL수평명현고우E2(P=0.005).E4기인형환자적병변최장장도명현장우E2기인형자(P=0.023),병변적분E4기인형자명현대우E2,E3자(P균=0.014).다중회귀분석현시병변적분여병변지수、범위급기인형명현상관(b=8.118,10.356,5.187;P=0.002,0.020,0.056),Logistic회귀분석현시서장압、담고순농도、삼선감유농도、HDL-C농도화병변적분여기인형명현상관(b=0.079,0.893,-1.014,-3.413,0.049;P=0.033,0.032,0.027,0.040,0.039).결론:남성관심병환자ApoE적기인다태성영향혈지대사화병정,여질병엄중정도밀절상관.
