中国中西医结合杂志
中國中西醫結閤雜誌
중국중서의결합잡지
CHINESE JOURNAL OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2010年
4期
357-360
,共4页
吴同启%顾宁%王芳芳%汪静%庞家华
吳同啟%顧寧%王芳芳%汪靜%龐傢華
오동계%고저%왕방방%왕정%방가화
宁心痛颗粒%益气活血法%冠心病%左室舒张功能不全
寧心痛顆粒%益氣活血法%冠心病%左室舒張功能不全
저심통과립%익기활혈법%관심병%좌실서장공능불전
Ningxintong Granule%qi-enriching and blood-activating therapy%coronary heart disease%left ventricular diastolic dysfunction
目的 观察宁心痛颗粒对冠心痛气虚血瘀证患者左室舒张功能不全的影响.方法 将76例冠心病气虚血瘀证左室舒张功能不全患者随机分为治疗组(40例)与对照组(36例),对照组采用常规西药治疗,治疗组在常规西药的基础上加用宁心痛颗粒(由黄芪、葛根、川芎、毛冬青、细辛制成,每包10 g)每次1包,每天3次,疗程4周.采用多普勒超声心动图检测治疗前后左室舒张功能指标舒张早期二尖瓣血流峰值(Emas)、舒张晚期二尖瓣血流峰值(Amas)及两者之比值(E/A),E峰减速度时间(DT)和等容舒张时间(IVRT),并观察临床疗效及中医证候疗效.结果 治疗组Emas、E/A增加,Amas、DT、IVRT降低,与治疗前及对照组治疗后比较,差异均有统计学意义(P＜0.05);中医证候疗效及临床疗效亦优于对照组.结论 具有益气活血功能的宁心痛颗粒对气虚血瘀证冠心病左室舒功能不全患者具有明显改善作用.
目的 觀察寧心痛顆粒對冠心痛氣虛血瘀證患者左室舒張功能不全的影響.方法 將76例冠心病氣虛血瘀證左室舒張功能不全患者隨機分為治療組(40例)與對照組(36例),對照組採用常規西藥治療,治療組在常規西藥的基礎上加用寧心痛顆粒(由黃芪、葛根、川芎、毛鼕青、細辛製成,每包10 g)每次1包,每天3次,療程4週.採用多普勒超聲心動圖檢測治療前後左室舒張功能指標舒張早期二尖瓣血流峰值(Emas)、舒張晚期二尖瓣血流峰值(Amas)及兩者之比值(E/A),E峰減速度時間(DT)和等容舒張時間(IVRT),併觀察臨床療效及中醫證候療效.結果 治療組Emas、E/A增加,Amas、DT、IVRT降低,與治療前及對照組治療後比較,差異均有統計學意義(P＜0.05);中醫證候療效及臨床療效亦優于對照組.結論 具有益氣活血功能的寧心痛顆粒對氣虛血瘀證冠心病左室舒功能不全患者具有明顯改善作用.
목적 관찰저심통과립대관심통기허혈어증환자좌실서장공능불전적영향.방법 장76례관심병기허혈어증좌실서장공능불전환자수궤분위치료조(40례)여대조조(36례),대조조채용상규서약치료,치료조재상규서약적기출상가용저심통과립(유황기、갈근、천궁、모동청、세신제성,매포10 g)매차1포,매천3차,료정4주.채용다보륵초성심동도검측치료전후좌실서장공능지표서장조기이첨판혈류봉치(Emas)、서장만기이첨판혈류봉치(Amas)급량자지비치(E/A),E봉감속도시간(DT)화등용서장시간(IVRT),병관찰림상료효급중의증후료효.결과 치료조Emas、E/A증가,Amas、DT、IVRT강저,여치료전급대조조치료후비교,차이균유통계학의의(P＜0.05);중의증후료효급림상료효역우우대조조.결론 구유익기활혈공능적저심통과립대기허혈어증관심병좌실서공능불전환자구유명현개선작용.
Objective To investigate the effect of Ningxintong Granule(NXTG)on left ventricular diastolic dysfunction(LVDD)in patients with coronary heart disease(CHD)of qi-deficiency and blood-stasis syndrome in Chinese medicine.Methods Seventy-six CHD patients with LVDD of qi-deficiency blood-stasis syndrome were randomized into two groups.The 36 patients in the control group were treated by Western medical conventional treatment alone,and 40 patients in the treated group were treated by NXTG(Consisting of milkvetch root,pueraria root,ligustici,ilexpuhesceus,manchurian wildginger,10 g in each package)and Western medical conventional treatment in combination,one package each time,thrice daily,4 weeks as one the rapeutic course.The left ventricular function(LVF)of all patients(including Emas,Amas,E/A,DT and IVRT)was evaluated by Doppler echocardiography before and after treatment,and the changes of clinical effectiveness and TCM syndrome effectiveness were observed.Results Compared with the control group after treatment,Emas,E/A increased,while Amas,DT,IVRT decreased showing statistical difference(P＜0.05).The therapeutic effects in the treated group were significantly better(P＜0.05).Conclusion NXTG with qi-enriching and blood-activating actions shows favorable effect in treating CHD patients with LVDD.
