CAJ | 학술논문

目的调查精神分裂症患者代谢综合征的患病率及相关影响因素.方法 503名住院精神分裂症患者和60名健康自愿者接受调查,收集人口学资料和病史资料,测量相关生理和生化指标,按CDS和IDF标准诊断MS.结果精神分裂症患者MS的患病率分别为12.1％(CDS标准)和28.4％(IDF标准),显著高于对照组,女性患者患病率(15.3％或39.8％)高于男性患者(10.4％或22.4％),40岁以上患者的患病率(14.3％或30.9％)高于39岁以下患者(6.4％或22.1％)；血脂异常(TG增高和HDL-C降低)、肥胖(BMI和腰围)和血糖增高是最重要的危险因素(OR值＞6.0),总胆固醇增高、高血压、LDL-C增高、尿酸增高、女性、在婚和偏执型也是重要的危险因素(OR值＞2.0)；逐步判别分析显示甘油三酯(0.569)、体质量指数(0.451)、HDL-C(- 0.298)、性别(0.297)、年龄(0.294)和LDL-C (0.210)等6个因素对MS有独立鉴别作用.结论精神分裂症患者MS患病率显著高于一般人群,女性患者高于男性患者,年长患者高于年轻患者,血脂异常、肥胖和血糖增高是最重要的危险因素和预测指标.
목적 조사정신분렬증환자대사종합정적환병솔급상관영향인소.방법 503명주원정신분렬증환자화60명건강자원자접수조사,수집인구학자료화병사자료,측량상관생리화생화지표,안CDS화IDF표준진단MS.결과 정신분렬증환자MS적환병솔분별위12.1％(CDS표준)화28.4％(IDF표준),현저고우대조조,녀성환자환병솔(15.3％혹39.8％)고우남성환자(10.4％혹22.4％),40세이상환자적환병솔(14.3％혹30.9％)고우39세이하환자(6.4％혹22.1％)；혈지이상(TG증고화HDL-C강저)、비반(BMI화요위)화혈당증고시최중요적위험인소(OR치＞6.0),총담고순증고、고혈압、LDL-C증고、뇨산증고、녀성、재혼화편집형야시중요적위험인소(OR치＞2.0)；축보판별분석현시감유삼지(0.569)、체질량지수(0.451)、HDL-C(- 0.298)、성별(0.297)、년령(0.294)화LDL-C (0.210)등6개인소대MS유독립감별작용.결론 정신분렬증환자MS환병솔현저고우일반인군,녀성환자고우남성환자,년장환자고우년경환자,혈지이상、비반화혈당증고시최중요적위험인소화예측지표.
Objective To investigate prevalence of metabolic syndrome (MS) and related factors in patients with schizophrenia.Methods Five hundred and three inpatients with schizophrenia and 60 healthy volunteers were included in this study.The demographic information and medical data of these participants were recorded,and their physiological and biochemical parameters were measured,the MS was diagnosed according to CDand IDF criteria.Results The MS prevalence in patients with schizophrenia was 12.1％ according to CDS criteria and 28.4％ based on IDF standard,significantly higher than control group; the prevalence of MS was higher among female patients ( 15.3％ or 39.8％ ) than male patients ( 10.4％ or 22.4％ ) ; the prevalence of MS was higher among patients aged 40 or over ( 14.3％ or 30.9％ ) than patients aged 40 below (6.4％ or 22.1％ ).Dyslipidaemia (elevated TG and reduced HDL-C),obesity (BMI and waist) and increased blood glucose were the most important risk factors ( OR value ＞ 6.0),increased total cholesterol,high blood pressure,elevated LDL-C,increased uric acid,female,in marriage,and paranoid type were also important risk factors (OR value ＞ 2.0).Stepwise discriminate analysis showed triglyceride (0.569),BMI (0.451 ),HDL-C ( -0.298 ),gender (0.297 ),age (0.294)and LDL-C (0.210) 6 factors had a separate identification role in MS.Conclusion The prevalence of MS in patients with schizophrenia in significantly higher than that in the general population,females are higher than males in the patients with patients,and older patients are higher than younger patients.Dyslipidemia,obesity and elevated blood glucose are the most important risk factors and predictors of the MS.