CAJ | 학술논문

目的研究抑郁症患者的反应抑制能力情况.方法应用心理学试验软件E-prime对30名抑郁症患者(研究组)和年龄、性别、教育等方面与患者匹配的30名健康志愿者(对照组)进行反应抑制的行为学试验.试验为视觉的Go/NoGo范式,分为普通任务、对高兴情绪的反应抑制任务和对悲伤情绪的反应抑制任务三种.要求被试在看到Go刺激时按键,看到NoGo刺激时不按键.比较被试执行每组任务的反应时和正确率.结果 (1)在执行对高兴情绪的反应抑制任务时,研究组对Go刺激的反应正确率(0.85±0.12)显著高于(P＜0.05)对照组(0.75±0.15),对Nogo刺激的反应正确率(0.91 ±0.63)显著低于(P＜0.05)对照组(0.95±0.05)；(2)在执行普通的反应抑制任务时,研究组对Nogo刺激的反应正确率(0.95±0.04)显著低于(P＜0.05)对照组(0.97±0.03).(3)无论在执行哪种任务时,两组被试的反应时都没有显著差异(P＞0.05).结论与健康人相比,抑郁症患者对悲伤情绪刺激的识别倾向更高,对反应抑制任务的执行能力更低,这可能是抑郁症患者长期情绪低落并且生活、工作效率低下的原因.
목적 연구억욱증환자적반응억제능력정황.방법 응용심이학시험연건E-prime대30명억욱증환자(연구조)화년령、성별、교육등방면여환자필배적30명건강지원자(대조조)진행반응억제적행위학시험.시험위시각적Go/NoGo범식,분위보통임무、대고흥정서적반응억제임무화대비상정서적반응억제임무삼충.요구피시재간도Go자격시안건,간도NoGo자격시불안건.비교피시집행매조임무적반응시화정학솔.결과 (1)재집행대고흥정서적반응억제임무시,연구조대Go자격적반응정학솔(0.85±0.12)현저고우(P＜0.05)대조조(0.75±0.15),대Nogo자격적반응정학솔(0.91 ±0.63)현저저우(P＜0.05)대조조(0.95±0.05)；(2)재집행보통적반응억제임무시,연구조대Nogo자격적반응정학솔(0.95±0.04)현저저우(P＜0.05)대조조(0.97±0.03).(3)무론재집행나충임무시,량조피시적반응시도몰유현저차이(P＞0.05).결론 여건강인상비,억욱증환자대비상정서자격적식별경향경고,대반응억제임무적집행능력경저,저가능시억욱증환자장기정서저락병차생활、공작효솔저하적원인.
Objective To study the ability of response inhibition of depression.Methods 30 depressed patients( depression group) and 30 healthy subjects (control group)were recruited in this study.The two groups were age,gender and education matched.All the subjects performed three visual Go/Nogo tasks using E-prime.The three Go/Nogo tasks were Happy Nogo Task(HNT),Normal Task (NT)and Sad Nogo Task (SNT).The two groups were instructed to press a button as quickly and correctly as possible when the Go trials were presented,but not to response when the Nogo trials were presented.In each task,the differences of accuracy (ACC) and response Time (RT) between the two groups were compared.Results ( 1 ) In HNT,during Go trials,ACC of depression group ( 0.85 ± 0.12 ) was higher than that of control group (0.75 ± 0.15 ) (P ＜ 0.05 ) ; during Nogo trials,ACC of depression group ( 0.91 ± 0.63 ) was lower than that of control group ( 0.95 ± 0.05 ) (P ＜ 0.05 ).(2) In NT,During Nogo trials,ACC of depression group(0.95 ± 0.04) was higher than that of control group (0.97 ± 0.03 ) (P ＜0.05 ).(3) There were no significant differences in RT between the two groups in any trails (P ＞ 0.05 ).Conclusion Compared with control group,depressed patients have a much higher recognize incline to the stimulus of sad emotion and a lower ability to complete normal response inhibition task.This is a new way to explain the depression pathogenesis mechanisms.