CAJ | 학술논문

目的研究人类表皮生长因子受体-2(HER-2)在乳腺癌中的表达及其与肿瘤坏死因子-α(TNF-α)的相关性.方法 HER-2是武汉大学中南医院乳腺癌患者常规检测项目.我们采用免疫组化SABC法检测112例原发性乳腺癌组织中TNF-α的表达,分析HER-2在乳腺癌中的表达、HER-2与乳腺癌临床病理特征的关系以及HER-2和TNF-α的相关性.结果 (1)乳腺癌中HER-2的阳性表达率为35.71%(40/112),其中在97例浸润性导管癌中的阳性表达率为35.05%(34/97),在浸润性小叶癌中的阳性表达率为33.33%(2/6),在黏液腺癌中的阳性表达率为25.00%(1/4),在导管内癌中的阳性表达率为50.00%(2/4),1例小叶原位癌为HER-2阳性.HER-2在各类型乳腺癌中的差异无统计学意义(P＞0.05).(2)HER-2在乳腺癌中的表达与TNM分期、年龄、初潮年龄、是否绝经、孕次、产次、肿瘤家族史均无相关性(P均＞0.05).(3)HER-2阴性时TNF-α的阳性率为23.61%(17/72),HER-2阳性时TNF-α的阳性率为52.50%(21/40).HER-2和TNF-α在乳腺癌中的表达有显著正相关性(r=0.881,P＜0.05).结论 HER-2与TNF-α在乳腺癌中的表达有显著正相关性,具体机制有待更多研究.
목적 연구인류표피생장인자수체-2(HER-2)재유선암중적표체급기여종류배사인자-α(TNF-α)적상관성.방법 HER-2시무한대학중남의원유선암환자상규검측항목.아문채용면역조화SABC법검측112례원발성유선암조직중TNF-α적표체,분석HER-2재유선암중적표체、HER-2여유선암림상병리특정적관계이급HER-2화TNF-α적상관성.결과 (1)유선암중HER-2적양성표체솔위35.71%(40/112),기중재97례침윤성도관암중적양성표체솔위35.05%(34/97),재침윤성소협암중적양성표체솔위33.33%(2/6),재점액선암중적양성표체솔위25.00%(1/4),재도관내암중적양성표체솔위50.00%(2/4),1례소협원위암위HER-2양성.HER-2재각류형유선암중적차이무통계학의의(P＞0.05).(2)HER-2재유선암중적표체여TNM분기、년령、초조년령、시부절경、잉차、산차、종류가족사균무상관성(P균＞0.05).(3)HER-2음성시TNF-α적양성솔위23.61%(17/72),HER-2양성시TNF-α적양성솔위52.50%(21/40).HER-2화TNF-α재유선암중적표체유현저정상관성(r=0.881,P＜0.05).결론 HER-2여TNF-α재유선암중적표체유현저정상관성,구체궤제유대경다연구.
Objective To determine the expression of Human Epidermal Growth Factor Receptor 2 (HER-2) in breast cancer and its correlation with Tumor Necrosis Factor-α (TNF-α). Methods We used SABC method to detect the expression of HER-2 and TNF-α in 112 cases of primary breast cancer, and analyzed the association of HER-2 expression with clinicopathological features and TNF-α expression. Results The positive expression rate of HER-2 in breast cancer was 35.71% (40/112), of which, the expression rate was 35.05% (34/97) in 97 invasive tubic breast cancer, and 33.33% (2/6) in invasive lobular breast cancer,25.00% (1/4) in mucinous carcinoma, and 50. 00% (2/4) in intraductal carcinoma. There was no significant correlation between HER-2 and any clinicopathological features of primary breast cancer ( P ＞ 0. 05 ). The expression of HER-2 in breast cancer had no signiciant association with TNM stage, age, age of menarche,menopause, gravidity, parity and family history of cancer ( Ps ＞ 0. 05 ), The positive rate of TNF-α was 23.61% (17/72) when HER-2 was negative, whereas the positive rate of TNF-α was 52. 50% (21/40) when HER-2 was positive. The expression of HER-2 was signiciantly positively correlated with the expression of TNF-α (r = 0. 881, P ＜ 0. 05 ). Conclusion HER-2 expression had a positive correlation with TNF-α in breast cancer,but the specific mechanism is still unclear.